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UNITED STATES


SECURITIES AND EXCHANGE COMMISSION


Washington, D.C. 20549

SCHEDULE 14A

INFORMATION REQUIRED IN PROXY STATEMENT


SCHEDULE 14A INFORMATION



Proxy Statement Pursuant to Section 14(a) of the


Securities Exchange Act of 1934

Filed by the Registrant ☒

Filed by a Party other than the Registrant  ☐

Check the appropriate box:

☐

Preliminary Proxy Statement

☐

Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

☒

Definitive Proxy Statement

☐

Definitive Additional Materials

☐

Soliciting Material under §240.14a-12

§240.14a-12

IKENA ONCOLOGY, INC.


(Name of registrant as specified in its charter)



(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check all boxes that apply):

☒

No fee required.

☐

Fee paid previously with preliminary materials.

☐

Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

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LOGO

IKENA ONCOLOGY, INC.


645 Summer Street, Suite 101


Boston, MA 02210



NOTICE OF 20232024 ANNUAL MEETING OF STOCKHOLDERS



To be held June 9, 2023

7, 2024

Notice is hereby given that the 20232024 Annual Meeting of Stockholders, or Annual Meeting, of Ikena Oncology, Inc., will be held online on June 9, 20237, 2024 at 8:30 a.m. Eastern Time. You may attend the meeting virtually via the Internet at www.virtualshareholdermeeting.com/IKNA2023,IKNA2024, where you will be able to vote electronically and submit questions. You will need the 16-digit control number included with the Notice of Internet Availability of Proxy Materials being mailed to you separately in order to attend the Annual Meeting. The purpose of the Annual Meeting is the following:

1.
1.

To elect threetwo class IIIII directors to our boardBoard of directors,Directors, to serve until the 20262027 annual meeting of stockholders and until their successor has been duly elected and qualified, or until their earlier death, resignation or removal;

2.
2.

To ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2023;2024; and

3.
3.

To transact any other business properly brought before the Annual Meeting or any adjournment or postponement of the Annual Meeting.

The proposal for the election of directors relates solely to the election of threetwo class IIIII directors nominated by the boardBoard of directors.

Directors.

Only Ikena Oncology, Inc. stockholders of record at the close of business on April 18, 2023,10, 2024, will be entitled to vote at the Annual Meeting and any adjournment or postponement thereof.

Ikena Oncology, Inc. is following the Securities and Exchange Commission’s “Notice and Access” rule that allows companies to furnish their proxy materials by posting them on the Internet. As a result, we are mailing to our stockholders a Notice of Internet Availability of Proxy Materials, or the Notice, instead of a paper copy of the accompanying proxy statement and our Annual Report for the fiscal year ended December 31, 2022,2023, or the 20222023 Annual Report. We plan to mail the Notice on or about April 28, 2023,26, 2024, and it contains instructions on how to access both the 20222023 Annual Report and accompanying proxy statement over the Internet. This method provides our stockholders with expedited access to proxy materials and not only lowers the cost of printing and distribution but also reduces the environmental impact of the Annual Meeting. If you would like to receive a print version of the proxy materials, free of charge, please follow the instructions on the Notice.

Please see the “General Information” section of the proxy statement that accompanies this notice for more details regarding the logistics of the virtual Annual Meeting, including the ability of stockholders to submit questions during the Annual Meeting, and technical details and support related to accessing the virtual platform.

Your vote is important. Whether or not you expect to attend the virtual meeting, it is important that your shares be represented. To ensure that your vote is recorded promptly, please vote as soon as possible, even if you plan to attend the meeting, by submitting your proxy via the Internet at the website provided on the proxy card or by signing, dating and returning the proxy card. Even if you have voted by proxy, you may still vote at the virtual

meeting. Please note, however, that if your shares are held through a broker, bank or other nominee and you wish to vote at the meeting, you must obtain a proxy issued in your name from that record holder.

​
​By order of the Board of Directors,
​​

​

/s/ Mark Manfredi

​

Mark Manfredi, Ph.D.


President and Chief Executive Officer
Boston, MA
April 26, 2024

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TABLE OF CONTENTS
Proxy Statement for the 2024 Annual Meeting of Stockholders
​​
1
General Information
​​
2
Proposal No. 1 – Election of Class II Directors
​​
6
Proposal No. 2 – Ratification of the Appointment of Ernst & Young LLP as Ikena Oncology, Inc.’s Independent Registered Public Accounting Firm for the Fiscal Year Ending December 31, 2024
​​
12
Corporate Governance
​​
13
Director Compensation
​​
19
Executive Officers
​​
21
Executive Compensation
​​
22
Certain Relationships and Related Party Transactions
​​
27
Principal Stockholders
​​
29
Report of the Audit Committee
​​
32
Householding
​​
33
Stockholder Proposals
​​
33
Other Matters
​​
33

Boston, MA

April 28, 2023

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Page

PROXY STATEMENT FOR THE 2023 ANNUAL MEETING OF STOCKHOLDERS

1

GENERAL INFORMATION

3

PROPOSAL NO. 1 – ELECTION OF CLASS II DIRECTORS

7

PROPOSAL NO. 2 – RATIFICATION OF THE APPOINTMENT OF ERNST  & YOUNG LLP AS IKENA ONCOLOGY, INC.’S INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE FISCAL YEAR ENDING DECEMBER 31, 2023

12

CORPORATE GOVERNANCE

14

CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS

30

PRINCIPAL STOCKHOLDERS

32

REPORT OF THE AUDIT COMMITTEE

36

HOUSEHOLDING

37

STOCKHOLDER PROPOSALS

37

OTHER MATTERS

38

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LOGO

IKENA ONCOLOGY, INC.


645 Summer Street, Suite 101


Boston, MA 02210

PROXY STATEMENT


FOR THE 20232024 ANNUAL MEETING OF STOCKHOLDERS



TO BE HELD June 9, 2023

7, 2024

This proxy statement contains information about the 20232024 Annual Meeting of Stockholders, or the Annual Meeting, of Ikena Oncology, Inc., which will be held virtually on June 9, 20237, 2024 at 8:30 a.m. Eastern Time. This year’s Annual Meeting will be held virtually, both to increase accessibility and encourage participation from our stockholders. You may attend the Annual Meeting virtually at www.virtualshareholdermeeting.com/IKNA2023,IKNA2024, where you will be able to vote electronically and submit questions. You will need the 16-digit control number included with the Notice of Internet Availability of Proxy Materials being mailed to you separately in order to attend the Annual Meeting. The boardBoard of directorsDirectors of Ikena Oncology, Inc. is using this proxy statement to solicit proxies for use at the Annual Meeting. In this proxy statement, the terms “Ikena,” “Ikena Oncology,” the “Company,” “we,” “us,” and “our” refer to Ikena Oncology, Inc.

All properly submitted proxies will be voted in accordance with the instructions contained in those proxies. If no instructions are specified, the proxies will be voted in accordance with the recommendation of our boardBoard of directorsDirectors with respect to each of the matters set forth in this proxy statement and the accompanying proxy card. You may revoke your proxy at any time before it is exercised at the meeting by giving our corporate secretaryCorporate Secretary written notice to that effect.

This proxy statement and our 20222023 Annual Report on Form 10-K for the fiscal year ended December 31, 2022,2023, or the 20222023 Annual Report, are first being mailed to stockholders on or about April 28, 2023.

26, 2024.

We are an “emerging growth company” under applicable federal securities laws and therefore permitted to conform with certain reduced public company reporting requirements. As an emerging growth company, we provide in this proxy statement the scaled disclosure permitted under the Jumpstart Our Business Startups Act of 2012, or the JOBS Act, including the compensation disclosures required of a “smaller reporting company,” as that term is defined in Rule 12b-2 promulgated under the Securities Exchange Act of 1934, as amended, or the Exchange Act. In addition, as an emerging growth company, we are not required to conduct votes seeking approval, on an advisory basis, of the compensation of our named executive officers or the frequency with which such votes must be conducted. We will remain an “emerging growth company” until the earliest of (i) the last day of the fiscal year following the fifth anniversary of our initial public offering in March 2021; (ii) the last day of the fiscal year in which our total annual gross revenue is equal to or more than $1.235 billion; (iii) the date on which we have issued more than $1 billion in nonconvertible debt during the previous three years; or (iv) the date on which we are deemed to be a large accelerated filer under the rules of the Securities and Exchange Commission, or the SEC. Even after we are no longer an “emerging growth company,” we may remain a “smaller reporting company.”

Important Notice Regarding the Availability of Proxy Materials for


the Annual Meeting of Stockholders to be Held on June 9, 2023:

7, 2024:


This proxy statement and our 20222023 Annual Report to Stockholders are


available for viewing, printing and downloading at www.ProxyVote.com.

www.ProxyVote.com.

A copy of this proxy statement and our 20222023 Annual Report, as filed with the SEC, except for exhibits, will be furnished without charge to any stockholder upon written request to Ikena Oncology, Inc., 645 Summer Street, Suite 101, Boston, Massachusetts 02210, Attention: Corporate Secretary. This proxy statement and our 20222023 Annual Report are also available on the SEC’s website at www.sec.gov. www.sec.gov.

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IKENA ONCOLOGY, INC.


PROXY STATEMENT


FOR THE 20232024 ANNUAL MEETING OF STOCKHOLDERS



GENERAL INFORMATION

Why are you holding a virtual Annual Meeting?

This year’s Annual Meeting will be held virtually, both to increase accessibility and encourage participation from our stockholders. We have implemented the virtual format in order to facilitate stockholder attendance at our Annual Meeting. We have designed our virtual format to enhance, rather than constrain, stockholder access, participation and communication. For example, the virtual format allows stockholders to communicate with us during the Annual Meeting so they can ask questions of our boardBoard of directorsDirectors or management.

How do I attend and participate in the Annual Meeting online?

To attend and participate in the Annual Meeting, stockholders will need to access the live audio webcast of the meeting. To do so, stockholders of record will need to visit www.virtualshareholdermeeting.com/IKNA2023IKNA2024 and use their control number provided in the proxy card to preregister to this website, and beneficial owners of shares held in street name will need to follow the same instructions. Registration will open 15 minutes prior to the meeting.

The live audio webcast of the Annual Meeting will begin promptly at 8:30 a.m. Eastern Time.

How can I get help if I have trouble checking in or listening to the meeting online?

There will be a support number available on the login page of the virtual meeting 15 minutes before the meeting begins for any shareholders having technical difficulties. The technical support line will not be able to provide control numbers but will be able to assist with any technical issues.

When are this proxy statement and the accompanying materials scheduled to be sent to stockholders?

On or about April 28, 2023,26, 2024, we will mail this proxy statement and the accompanying proxy card or, for shares held in street name (i.e. held for your account by a broker or other nominee), a voting instruction form, and the 20222023 Annual Report. These materials are also available for viewing, printing and downloading on the Internet at www.ProxyVote.com.

Who is soliciting my vote?

Our Board of Directors or the board of directors, is soliciting your vote for the Annual Meeting.

When is the record date for the Annual Meeting?

The record date for determination of stockholders entitled to vote at the Annual Meeting is the close of business on April 18, 2023.

10, 2024.

How many votes can be cast by all stockholders?

There were 30,049,52841,889,525 shares of our voting common stock, par value $0.001 per share, outstanding on April 18, 2023,10, 2024, all of which are entitled to vote with respect to all matters to be acted upon at the Annual Meeting. Each stockholder of record is entitled to one vote for each share of our common stock held by such stockholder. As the stockholder of record, you have the right to grant your voting proxy directly to the individuals listed on the proxy

card or vote on your own behalf at our virtual Annual Meeting. None of our shares of preferred stock were outstanding as of April 18, 2023.10, 2024. As of April 18, 2023,10, 2024, there were 6,215,4656,368,586 shares of non-voting common stock, par value $0.001 per share, outstanding. The shares of non-voting stock are not entitled to vote on the proposals presented at the Annual Meeting.

Who is entitled to vote?

Registered Stockholders. If shares of our voting common stock are registered directly in your name with our transfer agent, you are considered the stockholder of record with respect to those shares. As the stockholder of record, you have the right to grant your voting proxy directly to the individuals listed on the proxy card or vote on your own behalf at our virtual Annual Meeting. Throughout this proxy statement, we refer to these registered stockholders as “stockholders of record.”
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Street Name Stockholders. If shares of our voting common stock are held on your behalf in a brokerage account or by a bank or other nominee, you are considered to be the beneficial owner of shares that are held in “street name,” and the proxy materials were forwarded to you by your broker or nominee, who is considered the stockholder of record with respect to those shares. As the beneficial owner, you have the right to direct your broker, bank or other nominee as to how to vote your shares. Beneficial owners are also invited to attend our virtual Annual Meeting. However, since a beneficial owner is not the stockholder of record, you may not vote your shares of our common stock on your own behalf at the Annual Meeting unless you follow your broker’s procedures for obtaining a legal proxy. Note you should also be receiving a voting instruction form for you to use from your broker. Throughout this proxy statement, we refer to stockholders who hold their shares through a broker, bank or other nominee as “street name stockholders.”

How do I vote?

If you are a stockholder of record, there are four ways to vote:

•

By Internet. You may vote at www.ProxyVote.com, 24 hours a day, seven days a week. Use the Internet to transmit your voting instructions and for electronic delivery of information up until 11:59 p.m. Eastern Time the day before the meeting date. You will need the control number included on your proxy card.

•

During the Annual Meeting. You may vote during the Annual Meeting by going to www.virtualshareholdermeeting.com/IKNA2023. You will need the control number included on your proxy card.

•

By Telephone. You may vote using a touch-tone telephone by calling 1-800-690-6903, 24 hours a day, seven days a week. Use any touch-tone telephone to transmit your voting instructions up until 11:59 p.m. Eastern Time the day before the meeting date. You will need the control number included on your proxy card.

•

By Mail. You may vote by completing and mailing your proxy card. Mark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717.

By Internet. You may vote at www.ProxyVote.com, 24 hours a day, seven days a week. Use the Internet to transmit your voting instructions and for electronic delivery of information up until 11:59 p.m. Eastern Time the day before the meeting date. You will need the control number included on your proxy card.
During the Annual Meeting. You may vote during the Annual Meeting by going to www.virtualshareholdermeeting.com/IKNA2024. You will need the control number included on your proxy card.
By Telephone. You may vote using a touch-tone telephone by calling 1-800-690-6903, 24 hours a day, seven days a week. Use any touch-tone telephone to transmit your voting instructions up until 11:59 p.m. Eastern Time the day before the meeting date. You will need the control number included on your proxy card.
By Mail. You may vote by completing and mailing your proxy card. Mark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717.
Even if you plan to participate in our virtual Annual Meeting, we recommend that you also vote by proxy so that your vote will be counted if you later decide not to participate in the Annual Meeting.

If you are a street name stockholder, you will receive voting instructions from your broker, bank or other nominee. You must follow the voting instructions provided by your broker, bank or other nominee in order to instruct your broker, bank or other nominee on how to vote your shares. Street name stockholders should generally be able to vote by returning an instruction card, or by telephone or on the Internet. However, the availability of telephone and Internet voting will depend on the voting process of your broker, bank or other nominee. As discussed above, if you are a street name stockholder, you may not vote your shares on your own behalf at the Annual Meeting unless you obtain a legal proxy from your broker, bank or other nominee.

By Proxy

If you will not be attending the Annual Meeting, you may vote by proxy. You can vote by proxy over the Internet by following the instructions provided on the enclosed proxy card. Proxies submitted by mail must be received before the start of the Annual Meeting.

If you complete and submit your proxy before the Annual Meeting, the persons named as proxies will vote the shares represented by your proxy in accordance with your instructions. If you submit a proxy without giving voting instructions, your shares will be voted in the manner recommended by the boardBoard of directorsDirectors on all matters presented in this proxy statement and as the persons named as proxies may determine in their discretion with respect to any other matters properly presented at the Annual Meeting. You may also authorize another person or persons to act for you as proxy in a writing, signed by you or your authorized representative, specifying the details of those proxies’ authority. The original writing must be given to each of the named proxies, although it may be sent to them by electronic transmission if, from that transmission, it can be determined that the transmission was authorized by you.

If any other matters are properly presented for consideration at the Annual Meeting, including, among other things, consideration of a motion to adjourn the Annual Meeting to another time or place (including, without
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limitation, for the purpose of soliciting additional proxies), the persons named in your proxy and acting thereunder will have discretion to vote on those matters in accordance with their best judgment. We do not currently anticipate that any other matters will be raised at the Annual Meeting.

How do I revoke my proxy?

You may revoke your proxy by (1) entering a new vote by mail that we receive before the start of the Annual Meeting or over the Internet or via telephone, (2) attending and voting at the Annual Meeting online (although attendance at the Annual Meeting will not in and of itself revoke a proxy), or (3) by filing an instrument in writing revoking the proxy or another duly executed proxy bearing a later date with our Corporate Secretary. Any written notice of revocation or subsequent proxy card must be received by our Corporate Secretary prior to the taking of the vote at the Annual Meeting. Such written notice of revocation or subsequent proxy card should be sent to our principal executive offices at Ikena Oncology, Inc., 645 Summer Street, Suite 101, Boston, Massachusetts 02210, Attention: Corporate Secretary.

If a broker, bank or other nominee holds your shares, you must contact such broker, bank or nominee in order to find out how to change your vote.

How is a quorum reached?

Our Amended and Restated Bylaws, or bylaws, provide that a majority of the shares entitled to vote, present or represented by proxy, will constitute a quorum for the transaction of business at the Annual Meeting.

Under the Delaware General Corporation Law, shares that are voted “abstain” or “withheld” and broker “non-votes”“non-votes” are counted as present for purposes of determining whether a quorum is present at the Annual Meeting. If a quorum is not present, the meeting may be adjourned until a quorum is obtained.

How is the vote counted?

Under our bylaws, any proposal other than an election of directors is decided by a majority of the votes properly cast for and against such proposal, except where a larger vote is required by law or by our Fifth Amended and Restated Certificate of Incorporation, or certificate of incorporation, or bylaws. Abstentions and broker “non-votes”“non-votes” are not included in the tabulation of the voting results on any such proposal and, therefore, do not have an impact on such proposals. A broker “non-vote”“non-vote” occurs when a nominee holding shares for a beneficial owner does not vote on a particular proposal because the nominee does not have discretionary voting power with respect to that item and has not received instructions from the beneficial owner.

If your shares are held in “street name” by a brokerage firm, your brokerage firm is required to vote your shares according to your instructions. If you do not give instructions to your brokerage firm, the brokerage firm will still be able to vote your shares with respect to certain “discretionary” items, but will not be allowed to vote your shares with respect to “non-discretionary”“non-discretionary” items. Proposal No. 1 is a “non-discretionary”“non-discretionary” item. If you do not instruct your broker how to vote with respect to this proposal, your broker may not vote for this proposal, and those votes will be counted as broker “non-votes.“non-votes.” Proposal No. 2 is considered to be a discretionary item, and your brokerage firm will be able to vote on this proposal even if it does not receive instructions from you.

To be elected, the directors nominated via Proposal No. 1 must receive a plurality of the votes cast and entitled to vote on the proposal, meaning that the director nominees receiving the most votes will be elected. Shares voting “withheld” have no effect on the election of directors.

Who pays the cost for soliciting proxies?

We are making this solicitation and will pay the entire cost of preparing and distributing our proxy materials and soliciting votes. If you choose to access the proxy materials or vote over the Internet, you are responsible for any Internet access charges that you may incur. Our officers and employees may, without compensation other than their regular compensation, solicit proxies through further mailings, personal conversations, facsimile transmissions, e-mails or otherwise. Proxy solicitation expenses that we will pay include those for preparation, mailing, returning and tabulating the proxies.

How may stockholders submit matters for consideration at an Annual Meeting?

The required notice must be in writing and received by our corporate secretaryCorporate Secretary at our principal executive offices not less than 90 days nor more than 120 days prior to the first anniversary of the preceding year’s annual meeting. However, in the event that the date of the annual meeting is advanced by more than 30 days, or delayed
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by more than 60 days, from the first anniversary of the preceding year’s annual meeting, or if no annual meeting were held in the preceding year, a stockholder’s notice must be so received no earlier than the 120th day prior to such annual meeting and not later than the close of business on the later of (A) the 90th day prior to such annual meeting and (B) the tenth day following the day on which notice of the date of such annual meeting was mailed or public disclosure of the date of such annual meeting was made, whichever first occurs.

In addition, any stockholder proposal intended to be included in the proxy statement for the next annual meeting of our stockholders in 20242025 must also satisfy the requirements of SEC Rule 14a-8 under the Securities Exchange Act of 1934, as amended, or the Exchange Act, and be received not later than December 30, 2023.27, 2024. If the date of the annual meeting is moved by more than 30 days from the date contemplated at the time of the previous year’s proxy statement, then notice must be received within a reasonable time before we begin to print and send proxy materials. If that happens, we will publicly announce the deadline for submitting a proposal in a press release or in a document filed with the SEC.

How can I find out the results of the voting at the Annual Meeting?

We plan to announce preliminary voting results at the Annual Meeting. Final voting results will be published in a Current Report on Form 8-K, or Form 8-K, that we expect to file with the SEC within four business days after the Annual Meeting. If final voting results are not available to us in time to file a Form 8-K within four business days after the Annual Meeting, we intend to file a Form 8-K to publish preliminary results and, within four business days after the final results are known to us, to file an additional Form 8-K to publish the final results.
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PROPOSAL NO. 1 – ELECTION OF CLASS IIIII DIRECTORS

Our boardBoard of directorsDirectors currently consists of eight members. In accordance with the terms of our certificate of incorporation and bylaws, our boardBoard of directorsDirectors is divided into three classes, Class I, Class II and Class III, with members of each class serving staggered three-year terms. The members of the classes are divided as follows:

the Class I directors are Iain Dukes, D.Phil., Maria Koehler, M.D., Ph.D., and Otello Stampacchia, Ph.D., and their terms will expire at the annual meeting of stockholders to be held in 2025;

the Class II directors are David P. Bonita, M.D., Jean-François Formela, M.D., and Richard Wooster, Ph.D., and their terms will expire at the Annual Meeting;stockholders to be held in 2026; and

the Class III directors are Owen Hughes and Mark Manfredi, Ph.D., and their terms will expire at the annual meeting of stockholders to be held in 2024.

Annual Meeting.

Upon the expiration of the term of a class of directors, directors in that class will be eligible to be elected for a new three-year term at the annual meeting of stockholders in the year in which their term expires.

Our certificate of incorporation and bylaws provide that the authorized number of directors may be changed only by resolution of our boardBoard of directors.Directors. Our certificate of incorporation also provides that our directors may be removed only for cause by the affirmative vote of the holders of at least two thirds (2/3) or more of the outstanding shares then entitled to vote in an annual election of directors, and that any vacancy on our boardBoard of directors,Directors, including a vacancy resulting from an enlargement of our boardBoard of directors,Directors, may be filled only by vote of a majority of our directors then in office.

Our boardBoard of directorsDirectors has nominated David Bonita, M.D., Jean-François Formela, M.D.,Owen Hughes and Richard Wooster,Mark Manfredi, Ph.D. for re-election as Class IIIII directors at the Annual Meeting. The nominees are presently directors and have indicated a willingness to continue to serve as directors, if elected. If the nominees become unable or unwilling to serve, however, the proxies may be voted for substitute nominees selected by our boardBoard of directors.

Directors.

Our Nominating and Corporate Governance Committee Policies and Procedures for Director Candidates, or the Director Guidelines, provide that the value of diversity should be considered in determining director candidates as well as other factors such as a candidate’s character, judgment, skills, education, expertise and absence of conflicts of interest. However, we do not have a formal policy concerning the diversity of the boardBoard of directors.Directors. Our priority in selection of board members is identification of members who will further the interests of our stockholders through their established records of professional accomplishment, their ability to contribute positively to the collaborative culture among board members and their knowledge of our business and understanding of the competitive landscape in which we operate and adherence to high ethical standards. Although the nominatingNominating and corporate governance committeeCorporate Governance Committee does not have a formal diversity policy and does not follow any ratio or formula with respect to diversity in order to determine the appropriate composition of the boardBoard of directors,Directors, the nominatingNominating and corporate governance committeeCorporate Governance Committee and the full boardBoard of directorsDirectors are committed to creating a boardBoard of directorsDirectors with diversity, including diversity of expertise, experience, background, race and gender and are committed to identifying, recruiting and advancing candidates offering such diversity in future searches.
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Board Diversity Matrix

   As of April 18, 2023 
Total Number of Directors  8 
   Female   Male   Non-Binary   Did Not
Disclose
Gender		 

Part I: Gender Identity

        

Directors

   1    7    —      —   

Part II: Demographic Background

        

African American or Black

   —      —      —      —   

Alaskan Native or Native American

   —      —      —      —   

Asian

   —      —      —      —   

Hispanic or Latinx

   —      —      —      —   

Native Hawaiian or Pacific Islander

   —      —      —      —   

White

   1    4    —      —   

Two or More Races or Ethnicities

   —      —      —      —   

LGBTQ+

   —   

Did Not Disclose Demographic Background

   3 

As of April 10, 2024
​Total Number of Directors​​8​
​ ​​Female​​Male​​
Non-
Binary
​​
Did Not
Disclose
Gender
​
​
Part I: Gender Identity
​
​Directors​​1​​6​​—​​1​
​
Part II: Demographic Background
​
​African American or Black​​—​​—​​—​​—​
​Alaskan Native or Native American​​—​​—​​—​​—​
​Asian​​—​​—​​—​​—​
​Hispanic or Latinx​​—​​—​​—​​—​
​Native Hawaiian or Pacific Islander​​—​​—​​—​​—​
​White​​1​​3​​—​​—​
​Two or More Races or Ethnicities​​—​​—​​—​​—​
​LGBTQ+​​—​
​Did Not Disclose Demographic Background​​4​
In addition to the information presented below regarding each of the nominees and continuing directors’ specific experience, qualifications, attributes and skills that our boardBoard of directorsDirectors and our nominatingNominating and corporate governance committeeCorporate Governance Committee considered in determining that he or she should serve as a director, we also believe that each of our directors has demonstrated business acumen, integrity and an ability to exercise sound judgment, as well as a commitment of service to our company and our boardBoard of directors.

Directors.

Nominee for Election as Class IIIII Director

The following table identifies our director nominees and sets forth their principal occupation and business experience during the last five years and age as of March 31, 2023.

Name

  Positions and Offices Held with Ikena
Oncology, Inc.		  Director
Since		   Age 

David Bonita, M.D.

  Director   2016    47 

Jean-François Formela, M.D.

  Director   2016    66 

Richard Wooster, Ph.D.

  Director   2022    58 

David Bonita, M.D.April 1, 2024.

Name​​Positions and Offices Held with Ikena Oncology, Inc.​​
Director
Since
​​Age
Owen Hughes.
​​Chair of the Board of Directors and Director​​2022​​49
Mark Manfredi, Ph.D.
​​Chief Executive Officer and Director​​2017​​53
Owen Hughes has served as a memberChair of our boardBoard of directors since March 2016. Dr. Bonita is a member of OrbiMed Advisors LLC, an investment firm. Dr. Bonita currently serves on the boards of directors of Acutus Medical Inc. (Nasdaq: AFIB), Prelude Therapeutics, Inc. (Nasdaq: PRLD), Repare Therapeutics Inc. (Nasdaq: RPTX), and Third Harmonic Bio, Inc. (Nasdaq: THRD), as well as several private companies. Dr. Bonita also previously served on the boards of directors of Clementia Pharmaceuticals Inc., IMARA Inc., SI-BONE, Inc., Tricida, Inc., and ViewRay Inc. Prior to OrbiMed, Dr. Bonita worked as a corporate finance analyst in the healthcare investment banking groups of Morgan Stanley and UBS. He received his B.A. in biology from Harvard University and his joint M.D./M.B.A. from Columbia University. We believe that Dr. Bonita is qualified to serve on our board of directors based on his roles on several public and private boards of directors as well as his extensive experience in investing in healthcare companies.

Jean-François Formela, M.D. has served as a member of our board of directorsDirectors and as a member of our audit committeeAudit Committee and Compensation Committee since March 2016. Dr. Formela isDecember 2022. Mr. Hughes has served as the chief executive officer of XOMA Royalty Corporation (Nasdaq: XOMA), or XOMA, since January 2024, where he previously served as executive chair and interim chief executive officer since January 2023. His operational experience includes prior roles as chief executive officer of Sail Bio, Inc., chief executive officer, co-founder and member of the board of directors of Cullinan Oncology (Nasdaq: CGEM) as well as chief business officer and head of corporate development at Intarcia Therapeutics, Inc. Mr. Hughes also has 15 years in healthcare finance experience, including roles as director at Bain Capital, LP and portfolio manager at Pyramis Global Advisors LLC, a Fidelity Investments Company. Mr. Hughes currently a Partner at Atlas Ventureserves on the board of directors of XOMA and focuses on novel drug discovery approaches and therapeutics. Dr. Formela joined Atlas Venture in 1993 to build the U.S. life sciencesfranchise. Dr. Formela is a director and co-founder of IFM Therapeutics, Inc., IntelliaC4 Therapeutics, Inc. (Nasdaq: NTLA), KorroCCCC). He was the former chair of Radius Health and lead independent director of Translate Bio Inc., Modify Therapeutics, Inc. Scorpion Therapeutics, Inc.,until their sale to Gurnet Point Capital and Sail Bio. Inc.

Dr. FormelaSanofi, respectively. Mr. Hughes also previously served on the board of Translate Bio, Inc.directors of FS Development Corp. II (Nasdaq: TBIO), Spero Therapeutics, Inc. (Nasdaq: SPRO), and FSDC). Mr. Hughes holds a Bachelor’s in History from Dartmouth College.

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Mark Manfredi, Ph.D.F-Star Therapeutics, Inc. Dr. Formela is a founding member of the Partners Healthcare Innovation Growth BoardIkena Oncology and a former trustee of the Boston Institute of Contemporary Art. Dr. Formela received his Doctor of Medicine from Paris University School of Medicinehas served as our President and his Master of Business Administration from Columbia University. We believe Dr. Formela’s experience in the life sciences industry, as well as his practice of medicine, provides him with the qualificationsChief Executive Officer, and skills to serve as a director of our Company.

Richard Wooster, Ph.D., has served as a member of our boardBoard of directorsDirectors since January 2022.December 2017. Previously, Dr. Wooster also serves on the board of directors of Illuminating Drug Discovery Limited. From April 2019 to October 2021, Dr. WoosterManfredi served as theour Chief Scientific Officer of Translate Bio, Inc.from March 2016 until December 2017. Prior to that, from MarchApril 2015 to September 2017, Dr. Manfredi was an in-house oncology expert at Atlas Venture, a company that has founded multiple biotechnology companies and Dr. Manfredi currently serves as an advisor to Atlas Venture. Concurrently, from April 2015 to April 2019,2016, Dr. Wooster served asManfredi was the Presidentchief scientific officer of Research and Development and Chief Scientific Officer at TarvedaRaze Therapeutics, Inc., a biopharmaceuticalbiotechnology company (formerly knownfocused on oncology therapeutics that target key metabolic pathways. He also previously held roles of increasing responsibility at Millennium Pharmaceuticals, Inc., as Blend Therapeutics, Inc.). From May 2013 until March 2015, he acted as the Chief Scientific Officer of Tarveda Therapeutics andwell as its Presidentparent company, Takeda Pharmaceutical Company (NYSE: TAK) from January 2014April 2001 to MarchApril 2015. Prior to joining Tarveda Therapeutics, Dr. Wooster was Vice President and Discovery Performance Unit HeadManfredi holds a Bachelor of Science in Oncology at GlaxoSmithKline plc, a pharmaceutical company. During his academic career, Dr. Wooster discovered the breast cancer susceptibility gene BRCA2, was one of the founders of the Cancer Genome Project at the Welcome Trust Sanger Institute where mutations in BRAF were first discovered and developed the COSMIC mutation database and website. Dr. Wooster received a BSc in Biochemistry and a Ph.D. in drug metabolizing enzymesZoology from the University of Dundee, Scotland.Rhode Island and a Doctorate of Philosophy from Boston College. We believe that Dr. WoosterManfredi is qualified to serve onas our boardPresident and Chief Executive Officer and as a member of directors based onour Board of Directors because of his significant scientific and industry knowledge, as well as valuable experience in drug discoverygained from prior service as President and development and his management experience in the life sciences industry.

Chief Executive Officer.

The proxies will be voted in favor of the above nominees unless a contrary specification is made in the proxy. The nominees have consented to serve as our directors if elected. However, if the nominees are unable to serve or for good cause will not serve as a director, the proxies will be voted for the election of such substitute nominee as our boardBoard of directorsDirectors may designate.

The boardBoard of directorsDirectors recommends voting “FOR” the election of David Bonita, M.D., Jean-François Formela, M.D.,Owen Hughes and Richard Wooster,
Mark Manfredi, Ph.D. as Class IIIII directors, to serve for a three-year term ending
at the annual meeting of stockholders to be held in 2026.2027.
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Directors Continuing in Office

The following table identifies our directors, and sets forth their principal occupation and business experience during the last five years and their ages as of March 31, 2023.

Name

 

Positions and Offices Held with Ikena Oncology, Inc.

 Director
Since		  Class and Year
in Which Term
Will Expire		  Age 

Owen Hughes.

 Chairman of the Board of Directors and Director  2022   Class III—2024   48 

Mark Manfredi, Ph.D.

 Chief Executive Officer and Director  2017   Class III—2024   52 

Iain D. Dukes, D.Phil.

 Director  2016   Class I—2025   64 

Maria Koehler, M.D., Ph.D.

 Director  2021   Class I—2025   66 

Otello Stampacchia, Ph.D.

 Director  2020   Class I—2025   53 

April 1, 2024.

Name​​
Positions and Offices Held with
Ikena Oncology, Inc.
​​
Director
Since
​​
Class and Year
in Which Term
Will Expire
​​Age
Iain D. Dukes, D.Phil.
​​Director​​2016​​Class I—2025​​65
Maria Koehler, M.D., Ph.D.
​​Director​​2021​​Class I—2025​​67
Otello Stampacchia, Ph.D.
​​Director​​2020​​Class I—2025​​54
David P. Bonita, M.D.
​​Director​​2016​​Class II—2026​​48
Jean-François Formela, M.D.
​​Director​​2016​​Class II—2026​​67
Richard Wooster, Ph.D.
​​Director​​2022​​Class II—2026​​59
Class I Directors (Term Expires at 2025 Annual Meeting)

Iain D. Dukes, D.Phil.D.Phil. has served as a member of our boardBoard of directorsDirectors since November 2016. Dr. Dukes is a Venture Partnerventure partner at OrbiMed Advisors LLC, which he joined in August 2016. Dr. Dukes has served as the Chief Executive Officerchief executive officer of Viriom Inc. since February 2019, and has also served as the Executive Chairmanexecutive chair of Angiex Inc. since February 2020.2020 and the chief executive officer of Eilean Therapeutics LLC since July 2022. In June 2018, Dr. Dukes co-founded Theseus Pharmaceuticals, Inc. (Nasdaq: THRX) and currently serves as Chairmanchair of the Boardboard of directors. In September 2017, Dr. Dukes co-founded Kartos Therapeutics, Inc. and currently serves as President.president. Dr. Dukes previously served as Senior Vice Presidentsenior vice president and Headhead of Business Developmentbusiness development and Licensinglicensing for Merck Research Laboratories, or Merck, from August 2013 through May 2016. Prior to joining Merck, Dr. Dukes was Vice Presidentvice president of External Research & Development at Amgen, Inc. from August 2010 to August 2013. From October 2017 to July 2020, Dr. Dukes was a board member and Chairmanchair of KaNDy Therapeutics, which was acquired by Bayer AG in September 2020. From January 2020 to June 2020, Dr. Dukes served as supervisory board member of Themis BioScience GmbH, until it was acquired by Merck & Co. Dr. Dukes also co-founded Telios Pharmaceuticals, Inc., where he serves as President.president. Dr. Dukes currently serves on the boards of directors of NeRRe Therapeutics, ReViralRathlin Therapeutics Limited and ENYO Therapeutics. Since August 2016, Dr. Dukes has also served as chairmanchair of the board of directors of Iovance Biotherapeutics Inc. (Nasdaq: IOVA). He previously served on the board of directors of ReViral Limited until its acquisition by Pfizer Inc., or Pfizer, in June 2022. Dr. Dukes holds Master of Jurisprudence and Doctor of Philosophy degrees from the University of Oxford, a Master of Science degree in Cardiovascular Studies from the University of Leeds and a Bachelor of Science degree in Pharmacology from the University of Bath. We believe that Dr. Dukes is qualified to serve as a member of our boardBoard of directorsDirectors because of his extensive experience in the pharmaceutical industry, including his service in senior management roles.

Maria Koehler, M.D., Ph.D., has served on our boardBoard of directorsDirectors since April 2021. Dr. Koehler is a board-certified hematologist/oncologist and has more than 20 years of pharmaceutical and biotechnology experience. Since May 2019, Dr. Koehler has been Chief Medical Officerchief medical officer at Repare Therapeutics, Inc. (Nasdaq: RPTX), or Repare, a public precision oncology company. Prior to joining Repare, Dr. Koehler was Chief Medical Officerchief medical officer at Bicycle Therapeutics Limited (Nasdaq: BCYC), a public biopharmaceutical company, from September 2017 to April 2019, and before that had roles of increasing responsibility at Pfizer Inc. from 2009 through 2017, most recently as Vice Presidentvice president of Oncology Strategy, Innovation and Collaborations. Prior to joining Pfizer, Dr. Koehler was the group leader for the Medicine Development Center of GlaxoSmithKline Oncology. Prior to that, Dr. Koehler was a Senior Medical Directorsenior medical director for oncology research and development at AstraZeneca plc. She has also served as the clinical director of Bone Marrow Transplantation at University Hospital in Pittsburgh as well as the director of the Bone Marrow Transplant Program and associate professor at St. Christopher’s Hospital in Philadelphia. Dr. Koehler earned an M.D., and a Ph.D. in Toxicology from Silesian School of Medicine, Katowice, Poland. She received her initial training in immunology/oncology at the University of Heidelberg in Heidelberg, Germany, and additional training at St. Jude Children’s Research Hospital in the department of virology and molecular biology. Dr. Koehler currently serves on the board of directors of Abdera Therapeutics, Inc. and previously served on the board of directors of Celyad Oncology SA and Silverback Therapeutics, Inc. We believe Dr. Koehler is qualified to serve on our boardBoard of directorsDirectors because of her management experience in the biopharmaceuticals industry and her biotech oncology experience in clinical drug development.
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Otello Stampacchia, Ph.D.Ph.D. has served as a member of our boardBoard of directorsDirectors since December 2020. Dr. Stampacchia is founder, Managing Director,managing director and member of the investment committee at Omega Funds. Dr. Stampacchia currently serves on the boardboards of directors of Kronos Bio, Inc. (Nasdaq: KRON) and several private companies. Dr. Stampacchia previously served on the board of directors of Kronos Bio, Inc. (Nasdaq: KRON), Essa Pharma, Inc. (Nasdaq: EPIX), Gossamer Bio, Inc. (Nasdaq: GOSS), Median Technologies, Inc., Nuvation Bio, Inc. (NYSE: NUVB), and Replimune Group, Inc. (Nasdaq: REPL). Prior to founding Omega in January 2004, Dr. Stampacchia was a Partner at AlpInvest Partners (now part of The Carlyle Group). Before AlpInvest Partners, he was the portfolio manager of the Lombard Odier Immunology Fund, an investment vehicle in Geneva, Switzerland, investing in public and private healthcare companies worldwide. Previously, Dr. Stampacchia was a member of the HealthCare corporate finance and M&A team at Goldman Sachs. Before Goldman Sachs, he helped co-found the healthcare investment activities at Index Securities (now Index Ventures). Dr. Stampacchia received a Masters of Science in Plant Genetics from the University of Pavia, a Masters of Science in Molecular Biology, and a Doctorate of Philosophy in Molecular Biology from the University of Geneva and a Doctorate of Philosophy in Biotechnology from European Union Strasbourg. We believe Dr. Stampacchia is qualified to serve on our boardBoard of directorsDirectors because of his venture capital experience in the life sciences industry and his service on the boards of directors of other public and private life sciences companies.

Class IIIII Directors (Term Expires at 20242026 Annual Meeting)

Owen Hughes

David P. Bonita, M.D.has served as Chairmana member of our boardBoard of Directors since March 2016. Dr. Bonita is a member of OrbiMed Advisors LLC, an investment firm. Dr. Bonita currently serves on the boards of directors of Acutus Medical Inc. (Nasdaq: AFIB), Prelude Therapeutics, Inc. (Nasdaq: PRLD), Repare Therapeutics Inc. (Nasdaq: RPTX) and Third Harmonic Bio, Inc. (Nasdaq: THRD), as well as several private companies. Dr. Bonita also previously served on the boards of directors of Clementia Pharmaceuticals Inc., IMARA Inc. (Nasdaq: IMRA), SI-BONE, Inc. (Nasdaq: SIBM), Tricida, Inc. (Nasdaq: TCDAQ), and ViewRay Inc. Prior to OrbiMed, Dr. Bonita worked as a corporate finance analyst in the healthcare investment banking groups of Morgan Stanley and UBS. He received his B.A. in biology from Harvard University and his joint M.D./M.B.A. from Columbia University. We believe that Dr. Bonita is qualified to serve on our Board of Directors based on his roles on several public and private boards of directors as well as his extensive experience in investing in healthcare companies.
Jean-François Formela, M.D. has served as a member of our Board of Directors and as a member of our auditAudit Committee since March 2016. Dr. Formela is currently a partner at Atlas Venture and compensation committees since December 2022. Mr. Hughesfocuses on novel drug discovery approaches and therapeutics. Dr. Formela joined Atlas Venture in 1993 to build the U.S. life sciences franchise. Dr. Formela is the Chief Executive Officera director and co-founder of IFM Therapeutics, Inc., Korro Bio, Inc. (Nasdas: KRRO), Modify Therapeutics, Inc., Scorpion Therapeutics, Inc. and Sail Bio, Inc. Dr. Formela also previously served on the boards of directors of Intellia Therapeutics, Inc. (Nasdaq: NTLA), Translate Bio, Inc. (Nasdaq: TBIO), Spero Therapeutics, Inc. (Nasdaq: SPRO) and F-Star Therapeutics, Inc. (Nasdaq: FSTX). Dr. Formela is a privately held company founded in 2022. His operational experience includes prior roles as Chief Executive Officer, Co-Founder, and member of the boardMass General Brigham Innovation Advisory Board and a former trustee of directorsthe Boston Institute of Cullinan OncologyContemporary Art. Dr. Formela received his Doctor of Medicine from Paris University School of Medicine and his Master of Business Administration from Columbia University. We believe Dr. Formela’s experience in the life sciences industry, as well as Chief Business Officerhis practice of medicine, provides him with the qualifications and Headskills to serve as a director of Corporate Development at Intarcia Therapeutics, Inc. Mr. Hughesour Company.
Richard Wooster, Ph.D., has served as a member of our Board of Directors since January 2022. Dr. Wooster also has 15 years in healthcare finance experience, including roles as Director at Bain Capital, LP, and Portfolio Manager at Pyramis Global Advisors LLC, a Fidelity Investments Company. He currently serves as the Executive Chair and Interim CEO of Xoma Royalty, Inc. and was the former Chairman of Radius Health and Lead Independent Director of Translate Bio until their sale to Gurnet Point Capital and Sanofi, respectively. Mr. Hughes also previously served on the board of directors of FS Development Corp. II (Nasdaq FSDC). Mr. Hughes holds a Bachelor’s in History from Dartmouth College.

Mark Manfredi, Ph.D. is a founding member of Ikena Oncology and hasIlluminating Drug Discovery Limited. From April 2019 to October 2021, Dr. Wooster served as our President and Chief Executive Officer, and as a memberthe chief scientific officer of our board of directors since December 2017. Previously, Dr. Manfredi served as our Chief Scientific Officer from March 2016 until December 2017.Translate Bio, Inc. (Nasdaq: TBIO). Prior to that, from April 2015 to September 2017, Dr. Manfredi was an in-house oncology expert at Atlas Venture, a company that has founded multiple biotechnology companies and Dr. Manfredi currently serves as an advisor to Atlas Venture. Concurrently, from AprilMarch 2015 to April 2016,2019, Dr. Manfredi wasWooster served as the Chief Scientific Officerpresident of RazeResearch and Development and chief scientific officer at Tarveda Therapeutics, Inc., or Tarveda, a biotechnologybiopharmaceutical company focused on oncology therapeutics that target key metabolic pathways. He also previously held roles(formerly known as Blend Therapeutics, Inc.). From May 2013 until March 2015, he acted as the chief scientific officer of increasing responsibility at Millennium Pharmaceuticals, Inc., as wellTarveda and as its parent company, Takeda Pharmaceutical Companypresident from April 2001January 2014 to AprilMarch 2015. Prior to joining Tarveda, Dr. Manfredi holdsWooster was vice president and discovery performance unit head in Oncology at GlaxoSmithKline plc, a Bachelorpharmaceutical company. During his academic career, Dr. Wooster discovered the breast cancer susceptibility gene BRCA2, was one of Sciencethe founders of the Cancer Genome Project at the Welcome Trust Sanger Institute where mutations in ZoologyBRAF were first discovered and developed the COSMIC mutation database and website. Dr. Wooster received a BSc in Biochemistry and a Ph.D. in drug metabolizing enzymes from the University of Rhode Island, and a Doctorate of Philosophy from Boston College.Dundee, Scotland. We believe that Dr. ManfrediWooster is qualified to serve ason our PresidentBoard of Directors based on his experience in drug discovery and Chief Executive Officerdevelopment and as a member of our board of directors because of his significant scientific and industry knowledge, as well as valuablemanagement experience gained from prior service as President and Chief Executive Officer.in the life sciences industry.

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There are no family relationships between or among any of our directors or executive officers. The principal occupation and employment during the past five years of each of our directors was carried on, in each case except as specifically identified above, with a corporation or organization that is not a parent, subsidiary or other affiliate of us. There is no arrangement or understanding between any of our directors and any other person or persons pursuant to which he or she is to be selected as a director.

There are no material legal proceedings to which any of our directors is a party adverse to us or any of our subsidiaries or in which any such person has a material interest adverse to us.
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PROPOSAL NO. 2 – RATIFICATION OF THE APPOINTMENT OF ERNST & YOUNG LLP
AS IKENA ONCOLOGY, INC.’S INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
FOR THE FISCAL YEAR ENDING DECEMBER 31, 2023

2024

Ikena’s stockholders are being asked to ratify the appointment by the audit committeeAudit Committee of the boardBoard of directorsDirectors of Ernst & Young LLP as Ikena’s independent registered public accounting firm for the fiscal year ending December 31, 2023.2024. Ernst & Young LLP has served as Ikena’s independent registered public accounting firm since 2019.

The audit committeeAudit Committee is solely responsible for selecting Ikena’s independent registered public accounting firm for the fiscal year ending December 31, 2023.2024. Stockholder approval is not required to appoint Ernst & Young LLP as Ikena’s independent registered public accounting firm. However, the boardBoard of directorsDirectors believes that submitting the appointment of Ernst & Young LLP to the stockholders for ratification is good corporate governance. If the stockholders do not ratify this appointment, the audit committeeAudit Committee will reconsider whether to retain Ernst & Young LLP. If the selection of Ernst & Young LLP is ratified, the audit committee,Audit Committee, at its discretion, may direct the appointment of a different independent registered public accounting firm at any time it decides that such a change would be in the best interest of Ikena and its stockholders.

A representative of Ernst & Young LLP is expected to be present at the Annual Meeting and will have an opportunity to make a statement if he or she desires to do so and to respond to appropriate questions from our stockholders.

Ikena incurred the following fees from Ernst & Young LLP for the audit of the financial statements and for other services provided during the years ended December 31, 20222023 and 2021.

   2022   2021 

Audit fees (1)

  $675,363   $1,313,800 

Audit-Related fees

  $—     $—   

Tax fees (2)

  $—     $—   

All other fees (3)

  $2,000   $5,200 
  

 

 

   

 

 

 

Total fees

  $677,363   $1,319,000 
  

 

 

   

 

 

 

2022.
 ​​2023​​2022
Audit fees(1)
​​$969,750​​$675,363
Audit-Related fees
​​
$—
​​
$—
Tax fees(2)
​​
$—
​​
$—
All other fees(3)
​​
$—
​​
$2,000
Total fees
​​$969,750​​$677,363
(1)

Audit fees consist of fees billed for the audit of our annual financial statements, the review of our interim financial statements and services in connection with securities offerings, including registration statements, comfort letters and consents. In 2021, audit fees also included services in connection with the Company’s initial public offering.

(2)

Tax fees consist of fees for tax compliance, advice and tax planning and includes fees for tax return preparation.

(3)

Other fees consist of the annual subscription fee for Ernst & Young’sYoung LLP’s online accounting research tool.

Audit Committee Pre-approval Policy and Procedures

Our audit committeeAudit Committee has adopted policies and procedures relating to the approval of all audit and non-audit services that are to be performed by our independent registered public accounting firm. This policy provides that we will not engage our independent registered public accounting firm to render audit or non-audit services unless the service is specifically approved in advance by our audit committeeAudit Committee or the engagement is entered into pursuant to the pre-approval procedure described below.

From time to time, our audit committeeAudit Committee may pre-approve specified types of services that are expected to be provided to us by our independent registered public accounting firm during the next 12 months. Any such pre-approval details the particular service or type of services to be provided and is also generally subject to a maximum dollar amount.

During our 20222023 and 20212022 fiscal years, no services were provided to us by Ernst & Young LLP other than in accordance with the pre-approval policies and procedures described above.

The boardBoard of directorsDirectors recommends voting “FOR” Proposal No. 2 to ratify the appointment of
Ernst & Young LLP as Ikena Oncology, Inc.’s independent registered public accounting firm
for the fiscal year ending December 31, 2023.2024.
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CORPORATE GOVERNANCE

Director Nomination Process

Our nominatingNominating and corporate governance committeeCorporate Governance Committee is responsible for identifying individuals qualified to serve as directors, consistent with criteria approved by our boardBoard of directors,Directors and recommending such persons to be nominated for election as directors, except where we are legally required by contract, law or otherwise to provide third parties with the right to nominate.

The process followed by our nominatingNominating and corporate governance committeeCorporate Governance Committee to identify and evaluate director candidates includes requests to board members and others for recommendations, meetings from time to time to evaluate biographical information and background material relating to potential candidates and interviews of selected candidates by management, recruiters, members of the committee and our boardBoard of directors.Directors. The qualifications, qualities and skills that our nominatingNominating and corporate governance committeeCorporate Governance Committee believes must be met by a committee-recommended nominee for a position on our boardBoard of directorsDirectors are as follows:

Nominees should demonstrate high standards of personal and professional ethics and integrity.

Nominees should have proven achievement and competence in the nominee’s field and the ability to exercise sound business judgment.

Nominees should have skills that are complementary to those of the existing board.

Nominees should have the ability to assist and support management and make significant contributions to the Company’s success.

Nominees should have an understanding of the fiduciary responsibilities that are required of a member of the boardBoard of directorsDirectors and the commitment of time and energy necessary to diligently carry out those responsibilities.

Stockholders may recommend individuals to the nominatingNominating and corporate governance committeeCorporate Governance Committee for consideration as potential director candidates. Any such proposals should be submitted to our corporate secretaryCorporate Secretary at our principal executive offices no later than the close of business on the 90th day nor earlier than the close of business on the 120th day prior to the one-year anniversary of the date of the preceding year’s annual meeting and should include appropriate biographical and background material to allow the nominatingNominating and corporate governance committeeCorporate Governance Committee to properly evaluate the potential director candidate and the number of shares of our stock beneficially owned by the stockholder proposing the candidate. Stockholder proposals should be addressed to Ikena Oncology, Inc., 645 Summer Street, Suite 101, Boston, MA 02210, Attention: Corporate Secretary. Assuming that biographical and background material has been provided on a timely basis in accordance with our bylaws, any recommendations received from stockholders will be evaluated in the same manner as potential nominees proposed by the nominatingNominating and corporate governance committee.Corporate Governance Committee. If our boardBoard of directorsDirectors determines to nominate a stockholder-recommended candidate and recommends his or her election, then his or her name will be included on our proxy card for the next annual meeting of stockholders. See “Stockholder Proposals” for a discussion of submitting stockholder proposals.

Director Independence

Our common stock is listed on The Nasdaq Global Market.Market, or Nasdaq. Under the Nasdaq listing rules, independent directors must comprise a majority of a listed company’s board of directors within twelve months from the date of listing. In addition, the Nasdaq listing rules require that, subject to specified exceptions, each member of a listed company’s audit, compensation and nominating and corporate governance committees be independent within twelve months from the date of listing. Audit committee members must also satisfy additional independence criteria, including those set forth in Rule 10A-3 under the Securities Exchange Act of 1934, as amended, or the Exchange Act, and compensation committee members must also satisfy the independence criteria set forth in Rule 10C-1 under the Exchange Act. Under Nasdaq listing rules, a director will only qualify as an “independent

director” if, in the opinion of that company’s board of directors, that person does not have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director. In order to be considered independent for purposes of Rule 10A-3 under the Exchange Act, a member of an audit committee of a listed company may not, other than in his or her capacity as a member of the audit committee, the board of directors or any other board committee: (1) accept, directly or indirectly, any consulting, advisory, or other compensatory fee from the listed

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company or any of its subsidiaries, other than compensation for board service; or (2) be an affiliated person of the listed company or any of its subsidiaries. In order to be considered independent for purposes of Rule 10C-1, the board of directors must consider, for each member of a compensation committee of a listed company, all factors specifically relevant to determining whether a director has a relationship to such company which is material to that director’s ability to be independent from management in connection with the duties of a compensation committee member, including, but not limited to: the source of compensation of the director, including any consulting advisory or other compensatory fee paid by such company to the director, and whether the director is affiliated with the company or any of its subsidiaries or affiliates.

In April 2023,2024, our boardBoard of directorsDirectors undertook a review of the composition of our boardBoard of directorsDirectors and its committees and the independence of each director. Based upon information requested from and provided by each director concerning his or her background, employment and affiliations, including family relationships, our boardBoard of directorsDirectors has determined that all members of the boardBoard of directors,Directors, except Mark Manfredi, Ph.D., are independent directors, including for purposes of Nasdaq and the SEC rules. In making that determination, our boardBoard of directorsDirectors considered the relationships that each director has with us and all other facts and circumstances the boardBoard of directorsDirectors deemed relevant in determining independence, including the potential deemed beneficial ownership of our capital stock by each director and respective affiliations, including non-employee directors that are affiliated with certain of our major stockholders. We expect that the composition and functioning of our boardBoard of directorsDirectors and each of our committees will continue to comply with all applicable requirements of Nasdaq and the rules and regulations of the SEC. There are no family relationships among any of our directors or executive officers. Mark Manfredi, Ph.D. is not an independent director under these rules because he is currently employed as the chief executive officerChief Executive Officer and presidentPresident of our company.

Board Committees

Our boardBoard of directorsDirectors has established an audit committee,Audit Committee, a compensation committee,Compensation Committee and a nominatingNominating and corporate governance committee,Corporate Governance Committee, each of which operate pursuant to a charter adopted by our boardBoard of directors.Directors. We believe that the composition and functioning of all of our committees comply with the applicable requirements of Nasdaq, the Sarbanes-Oxley Act of 2002 and SEC rules and regulations that are applicable to us. We intend to comply with future requirements to the extent they become applicable to us.

The full text of our audit committee charter, compensation committee charterAudit Committee Charter, Compensation Committee Charter and nominatingNominating and corporate governance charterCorporate Governance Charter is posted on the investor relations portion of our website at www.ikenaoncology.com. We do not incorporate the information contained on, or accessible through, our corporate website into this prospectus, and you should not consider it a part of this prospectus.

Audit Committee

Jean-François Formela, M.D., Owen Hughes and Iain Dukes, D.Phil. currently serve on the audit committee,Audit Committee, which is chaired by Mr. Hughes. Ronald C. Renaud, Jr. served as chairOur Board of the audit committee until his tenure on our board of directors ended in December 2022. Our board of directorsDirectors has determined that each member of the audit committeeAudit Committee is “independent” for audit committeeAudit Committee purposes as that term is defined in the rules of the SEC and the applicable Nasdaq rules, and each has sufficient knowledge in financial and auditing matters to serve on the audit committee.Audit Committee. Our boardBoard of directorsDirectors has designated Mr. Hughes as an “audit committee financial expert,” as defined under the applicable rules of the SEC. During the fiscal year ended December 31, 2022,2023, the audit

committeeAudit Committee met four times. The report of the audit committeeAudit Committee is included in this proxy statement under “Report of the Audit Committee.” The audit committee’sAudit Committee’s responsibilities include:

appointing, approving the compensation of and assessing the independence of our independent registered public accounting firm;

pre-approving auditing and permissible non-audit services, and the terms of such services, to be provided by our independent registered public accounting firm;

reviewing the overall audit plan with our independent registered public accounting firm and members of management responsible for preparing our financial statements;

reviewing and discussing with management and our independent registered public accounting firm our annual and quarterly financial statements and related disclosures as well as critical accounting policies and practices used by us;

coordinating the oversight and reviewing the adequacy of our internal control over financial reporting;

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establishing policies and procedures for the receipt and retention of accounting-related complaints and concerns;

recommending, based upon the audit committee’sAudit Committee’s review and discussions with management and our independent registered public accounting firm, whether our audited financial statements shall be included in our Annual Report on Form 10-K;

monitoring the integrity of our financial statements and our compliance with legal and regulatory requirements as they relate to our financial statements and accounting matters;

preparing the audit committeeAudit Committee report required by SEC rules to be included in our annual proxy statement;

reviewing all related person transactions for potential conflict of interest situations and approving all such transactions; and

reviewing quarterly earnings releases.

releases; and

reviewing our company’s information security and technology risks (including cybersecurity), including high-level review of the threat landscape facing our company and our company’s strategy to mitigate cybersecurity risks and potential breaches.
All audit and non-audit services, other than de minimis non-audit services, to be provided to us by our independent registered public accounting firm must be approved in advance by our audit committee.

Audit Committee.

Compensation Committee

David P. Bonita, M.D., Jean-François Formela, M.D., and Owen Hughes currently serve on the compensation committee,Compensation Committee, which is chaired by Dr. Bonita. Ronald C. Renaud, Jr. served as a memberOur Board of the compensation committee until his tenure on our board of directors ended in December 2022. Our board of directorsDirectors has determined that each member of the compensation committeeCompensation Committee is “independent” as defined in the applicable Nasdaq rules. During the fiscal year ended December 31, 2022,2023, the compensation committee met four times.Compensation Committee did not meet. The compensation committee’sCompensation Committee’s responsibilities include:

reviewing and approving the corporate goals and objectives relevant to the compensation of our Chief Executive Officer;

evaluating the performance of our Chief Executive Officer in light of such corporate goals and objectives and based on such evaluation, recommending to the boardBoard of directorsDirectors the compensation of our Chief Executive Officer;

determining the compensation of our other executive officers and other company executives;

overseeing and administering our compensation and similar plans;

reviewing and approving the retention or termination of any consulting firm or outside advisor to assist in the evaluation of compensation matters and evaluating and assessing potential and current

compensation advisors in accordance with the independence standards identified in the applicable Nasdaq rules;

compensation advisors in accordance with the independence standards identified in the applicable Nasdaq rules;

retaining and approving the compensation of any compensation advisors;

reviewing and approving the grant of equity-based awards;

reviewing and recommending to the boardBoard of directorsDirectors the compensation of our directors; and

preparing our compensation committeeCompensation Committee report if and when required by SEC rules, if and when required, to be included in our annual proxy statement.

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Nominating and Corporate Governance Committee

David P. Bonita, M.D., Iain D. Dukes, D.Phil., and Otello Stampacchia, Ph.D. currently serve on the nominatingNominating and corporate governance committee,Corporate Governance Committee, which is chaired by Dr. Stampacchia. Our boardBoard of directorsDirectors has determined that each member of the nominatingNominating and corporate governance committeeCorporate Governance Committee is “independent” as defined in the applicable Nasdaq rules. During the fiscal year ended December 31, 2022,2023, the nominatingNominating and corporate governance committee met one time.Corporate Governance Committee did not meet. The nominatingNominating and corporate governance committee’sCorporate Governance Committee’s responsibilities include:

developing and recommending to the boardBoard of directorsDirectors criteria for board and committee membership;

establishing procedures for identifying and evaluating board of director candidates, including nominees recommended by stockholders;

reviewing the composition of the boardBoard of directorsDirectors to ensure that it is composed of members containing the appropriate skills and expertise to advise us;

identifying individuals qualified to become members of the boardBoard of directors;

Directors;

recommending to the boardBoard of directorsDirectors the persons to be nominated for election as directors and to each of the board’s committees;

reviewing and recommending to the boardBoard of directorsDirectors appropriate corporate governance guidelines; and

overseeing the evaluation of our boardBoard of directors.

Directors.

The nominatingNominating and corporate governance committeeCorporate Governance Committee considers candidates for boardBoard of directorsDirectors membership suggested by its members and the chief executive officer.Chief Executive Officer. Additionally, in selecting nominees for directors, the nominatingNominating and corporate governance committeeCorporate Governance Committee will review candidates recommended by stockholders in the same manner and using the same general criteria as candidates recruited by the committee and/or recommended by our boardBoard of directors.Directors. Any stockholder who wishes to recommend a candidate for consideration by the committee as a nominee for director should follow the procedures described later in this proxy statement under the heading “Stockholder Proposals.” The nominatingNominating and corporate governance committeeCorporate Governance Committee will also consider whether to nominate any person proposed by a stockholder in accordance with the provisions of our bylaws relating to stockholder nominations as described later in this proxy statement under the heading “Stockholder Proposals.”

Identifying and Evaluating Director Nominees. Our boardBoard of directorsDirectors is responsible for filling vacancies on our boardBoard of directorsDirectors and for nominating candidates for election by our stockholders each year in the class of directors whose term expires at the relevant annual meeting. The boardBoard of directorsDirectors delegates the selection and nomination process to the nominatingNominating and corporate governance committee,Corporate Governance Committee, with the expectation that other members of the boardBoard of directors,Directors, and of management, will be requested to take part in the process as appropriate.

Generally, the nominatingNominating and corporate governance committeeCorporate Governance Committee identifies candidates for director nominees in consultation with management, through the recommendations submitted by stockholders or through such other methods as the nominatingNominating and corporate governance committeeCorporate Governance Committee deems to be helpful to identify candidates. Once candidates have been identified, the nominatingNominating and corporate governance committeeCorporate Governance Committee confirms that the candidates meet all of the minimum qualifications for director nominees established by the nominatingNominating and corporate governance committee.Corporate Governance Committee. The nominatingNominating and corporate governance committeeCorporate Governance Committee may gather information about the candidates through interviews, detailed questionnaires, comprehensive background checks or any other means that the nominatingNominating and corporate governance committeeCorporate Governance Committee deems to be appropriate in the evaluation process. The nominatingNominating and corporate governance committeeCorporate Governance Committee then meets as a group to discuss and evaluate the qualities and skills of each candidate, both on an individual basis and taking into account the overall composition and needs of our boardBoard of directors.Directors. Based on the results of the evaluation process, the nominatingNominating and corporate governance committeeCorporate Governance Committee recommends candidates for the boardBoard of directors’Directors’ approval to fill a vacancy or as director nominees for election to the boardBoard of directorsDirectors by our stockholders each year in the class of directors whose term expires at the relevant annual meeting.

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Board and Committee Meetings Attendance

The full boardBoard of directorsDirectors met sixfive times during 2022.2023. During 2022,2023, each member of the boardBoard of directorsDirectors, with the exception of Otello Stampacchia, Ph.D. and Maria Koehler, M.D., Ph.D., participated in 75% or more of the aggregate of (i) the total number of meetings of the boardBoard of directorsDirectors (held during the period for which such person has been a director) and (ii) the total number of meetings held by all committees of the boardBoard of directorsDirectors on which such person served (during the periods that such person served).

Director Attendance at Annual Meeting of Stockholders

Directors are responsible for attending the annual meeting of stockholders to the extent practicable.

All members of our Board of Directors attended our annual meeting of stockholders in 2023.

Policy on Trading, Pledging and Hedging of Company Stock

Certain transactions in our securities (such as purchases and sales of publicly traded put and call options, and short sales) create a heightened compliance risk or could create the appearance of misalignment between management and stockholders. In addition, securities held in a margin account or pledged as collateral may be sold without consent if the owner fails to meet a margin call or defaults on the loan, thus creating the risk that a sale may occur at a time when an officer or director is aware of material, non-public information or otherwise is not permitted to trade in Company securities. Our insider trading policy expressly prohibits derivative transactions of our stock by our executive officers, directors, employees, consultants and designated contractors. Our insider trading policy expressly prohibits purchases of any derivative securities that provide the economic equivalent of ownership.

In accordance with the requirements of the SEC and Nasdaq listing rules, the Board of Directors has adopted a Compensation Recovery Policy, effective as of October 2, 2023. The Compensation Recovery Policy provides that, in the event we are required to prepare a restatement of financial statements due to material noncompliance with any financial reporting requirement under securities laws, we will seek to recover any incentive-based compensation that was based upon the attainment of a financial reporting measure and that was received by any current or former executive officer during the three-year period preceding the date that the restatement was required, if such compensation exceeds the amount that the executive officers would have received based on the restated financial statements.

Compensation Committee Interlocks and Insider Participation

During fiscal 2022,2023, David P. Bonita, M.D., Jean-François Formela, M.D., Ronald C. Renaud, Jr, and Owen Hughes, who replaced Ronald C. Renaud, Jr. in December 2022, were the only members of our compensation committee.Compensation Committee. None of the members of our compensation committeeCompensation Committee is, or has at any time during the prior three years been, one of our officers or employees. None of our executive officers currently serve, or have in the past fiscal year served, as a member of the boardBoard of directorsDirectors or compensation committeeCompensation Committee of any entity that has one or more of its executive officers serving as a member of our boardBoard of directorsDirectors or our compensation committee.

Compensation Committee.

Code of Business Conduct and Ethics

Our boardBoard of directorsDirectors adopted a Code of Business Conduct and Ethics in connection with our initial public offering in March 2021. The Code of Business Conduct and Ethics will apply to our directors, officers and employees, including our principal executive officer, principal financial officer, principal accounting officer, or

controller or persons performing similar functions. The full text of our Code of Business Conduct and Ethics is posted on our website at www.ikenaoncology.com. If we make any substantive amendments to, or grant any waivers from, our Code of Business Conduct and Ethics for any officer or director, we will disclose the nature of such amendment or waiver on our website or in a current report on Form 8-K.

Board Leadership Structure and Board’s Role in Risk Oversight

Owen Hughes is the current chairmanChair of our boardBoard of directors.Directors. We believe that separating the positions of chief executive officerChief Executive Officer and chairpersonChair of the boardBoard of directorsDirectors allows our chief executive officerChief Executive Officer to focus on our day-to-day business, while allowing a chairpersonChair of the board to lead the boardBoard of directorsDirectors in its fundamental role of providing advice to and independent oversight of management. Our boardBoard of directorsDirectors recognizes the time, effort and energy that the chief executive officerChief Executive Officer is required to devote to his position in the current business environment, as well as the commitment required to serve as our chairperson,Chair, particularly as the boardBoard of directors’ Directors’
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oversight responsibilities continue to grow. While our amended and restated bylaws and corporate governance guidelines do not require that our chairpersonChair and chief executive officerChief Executive Officer positions be separate, our boardBoard of directorsDirectors believes that having separate positions is the appropriate leadership structure for us at this time and demonstrates our commitment to good corporate governance. Risk is inherent to every business, and how well a business manages risk can ultimately determine its success. We face a number of risks, including risks relating to our financial condition, development and commercialization activities, operations, strategic direction and intellectual property. Management is responsible for the day-to-day management of risks we face, while our boardBoard of directors,Directors, as a whole and through its committees, has responsibility for the oversight of risk management. In its risk oversight role, our boardBoard of directorsDirectors has the responsibility to satisfy itself that the risk management processes designed and implemented by management are adequate and functioning as designed.

The role of the boardBoard of directorsDirectors in overseeing the management of our risks is conducted primarily through committees of the boardBoard of directors,Directors, as disclosed in the descriptions of each of the committees above and in the charters of each of the committees. The full boardBoard of directorsDirectors (or the appropriate board committee in the case of risks that are under the purview of a particular committee) discusses with management our major risk exposures, their potential impact on us and the steps we take to manage them. When a board committee is responsible for evaluating and overseeing the management of a particular risk or risks, the chairmanChair of the relevant committee reports on the discussion to the full boardBoard of directorsDirectors during the committee reports portion of the next board meeting. This enables the boardBoard of directorsDirectors and its committees to coordinate the risk oversight role, particularly with respect to risk interrelationships.

Communication with the Directors of Ikena Oncology, Inc.

Any interested party with concerns about our company may report such concerns to the boardBoard of directorsDirectors or the chairmanChair of our boardBoard of directorsDirectors or the chairmanChair of our nominatingNominating and corporate governance committee,Corporate Governance Committee, by submitting a written communication to the attention of such director at the following address:

c/o Ikena Oncology, Inc.


645 Summer Street, Suite 101


Boston, Massachusetts 02210


United States

You may submit your concern anonymously or confidentially by postal mail. You may also indicate whether you are a stockholder, customer, supplier or other interested party.

A copy of any such written communication may also be forwarded to Ikena’s legal counsel and a copy of such communication may be retained for a reasonable period of time. The director may discuss the matter with Ikena’s legal counsel, with independent advisors, with non-management directors, or with Ikena’s management, or may take other action or no action as the director determines in good faith, using reasonable judgment and applying his or her own discretion.

Communications may be forwarded to other directors if they relate to important substantive matters and include suggestions or comments that may be important for other directors to know. In general, communications relating to corporate governance and long-term corporate strategy are more likely to be forwarded than communications relating to ordinary business affairs, personal grievances and matters as to which we tend to receive repetitive or duplicative communications.

The audit committeeAudit Committee oversees the procedures for the receipt, retention and treatment of complaints received by Ikena Oncology regarding accounting, internal accounting controls, or audit matters, and the confidential, anonymous submission by employees of concerns regarding questionable accounting, internal accounting controls or auditing matters. Ikena Oncology has also established a toll-free telephone number for the reporting of such activity, which is 877-900-2988.
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DIRECTOR COMPENSATION

The following table presents the total compensation for each person who served as a non-employee member of our boardBoard of directorsDirectors and received compensation for such service during fiscal year 2022.2023. Other than as set forth in the table below, we did not pay any compensation, make any additional equity awards or non-equity awards to, or pay any other compensation to any of the non-employee members of our boardBoard of directorsDirectors in fiscal year 2022.2023. Directors who also serve as employees received no additional compensation for their service as directors. During fiscal year 2022,2023, Mark Manfredi, Ph.D., our President and Chief Executive Officer, was a member of our boardBoard of directors,Directors, as well as an employee, and received no additional compensation for his services as a director. See the section titled “20222023 Summary Compensation Table” for more information about his compensation in fiscal year 2022.

NAME  FEES
EARNED
OR
PAID IN
CASH ($)		   OPTION
AWARDS
($) (1)(2)		   TOTAL
($)		 

David Bonita, M.D.

   49,000    45,987    94,987 

Iain Dukes, D.Phil.

   39,000    45,987    84,987 

Jean-François Formela, M.D.

   47,500    45,987    93,487 

Ronald C. Renaud, Jr.

   85,000    45,987    130,987 

Otello Stampacchia, Ph.D.

   50,500    45,987    96,487 

Maria Koehler, M.D., Ph.D.

   35,000    45,987    80,987 

Richard Wooster, Ph.D.

   32,962    274,912    307,874 

Owen Hughes

   4,192    67,757    71,949 

2023.
Name​​
Fees Earned
or Paid in
Cash
($)
​​
Option
Awards
($)(1)(2)
​​
Total
($)
David Bonita, M.D.
​​49,000​​82,859​​131,859
Iain Dukes, D.Phil.
​​44,106​​82,859​​126,965
Jean-François Formela, M.D.
​​47,500​​82,859​​130,359
Otello Stampacchia, Ph.D.
​​45,389​​82,859​​128,248
Maria Koehler, M.D., Ph.D.
​​35,000​​82,859​​117,859
Richard Wooster, Ph.D.
​​35,000​​82,859​​117,859
Owen Hughes
​​85,000​​82,859​​167,859
(1)

The amounts reflect the grant date fair value of stock options granted in 20222023 in accordance with Financial Accounting Standards Board, or FASB, Accounting Standards Codification Topic 718, Compensation–Stock Compensation, or ASC Topic 718. Such grant date fair values do not take into account any estimated forfeitures related to service-based vesting conditions. The assumptions used in calculating the grant date fair value of the stock options reported in this column are set forth in the notes to consolidated financial statements included in our Annual Report on Form 10-K. The amounts reported in this column reflect the accounting cost for these stock options and do not correspond to the actual economic value that may be received by our non-employee directors upon the exercise of such options.

(2)

Non-employee directors who served on the Board of Directors during 20222023 had the following stock options outstanding as of December 31, 20222023 and held no shares of restricted stock:

Name​​
Aggregate
Number of
Shares Subject
to Stock Options
NAME
David P. Bonita, M.D.
​AGGREGATE NUMBER OF SHARES
SUBJECT TO STOCK OPTIONS​		44,358

David Bonita, M.D.

26,838

Iain Dukes, D.Phil.

​​273,258290,778

Jean-François Formela, M.D.

​​26,83844,358

Ronald C. Renaud, Jr.

162,801

Otello Stampacchia, Ph.D.

​​26,83844,358

Maria Koehler, M.D., Ph.D.

​​53,67671,196

Richard Wooster, Ph.D.

​​42,61960,139

Owen Hughes

​​35,04052,560
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Non-Employee Director Compensation Policy

In FebruaryDecember 2022, the Compensation Committee recommended, and the Board approved, pursuant to recommendations from our retained compensation consultant, Aon Radford, based on benchmarking against peer

companies, an amendment to our Non-Employee Director Compensation Policy.amended and restated non-employee director compensation policy, which became effective on December 15, 2022. The table below depicts the compensation elements of our Amended & Restated Non-Employee Director Compensation Policy, as amended, during 2022:

Annual Retainer for Board Membership

 

Annual service on the board of directors

 $35,000 

Additional Annual Retainer for Committee Membership

 

Annual service as member of the audit committee (other than chair)

 $7,500 

Annual service as chair of the audit committee

 $15,000 

Annual service as member of the compensation committee (other than chair)

 $5,000 

Annual service as chair of the compensation committee

 $10,000 

Annual service as member of the nominating and corporate governance committee (other than chair)

 $4,000 

Annual service as chair of the nominating and corporate governance committee

 $8,000 

Additional Annual Retainer for Non-Executive Chairman of the Board

 

Annual service as chairman of the board of directors

 $30,000 

Policy:

Annual Retainer for Board Membership
​​
Annual service on the Board of Directors
​​$35,000
Additional Annual Retainer for Committee Membership
​​
Annual service as member of the Audit Committee (other than Chair)
​​
$7,500
Annual service as Chair of the Audit Committee
​​$15,000
Annual service as member of the Compensation Committee (other than Chair)
​​
$5,000
Annual service as Chair of the Compensation Committee
​​$10,000
Annual service as member of the Nominating and Corporate Governance Committee (other than Chair)
​​
$4,000
Annual service as Chair of the Nominating and Corporate Governance Committee
​​
$8,000
Additional Annual Retainer for Non-Executive Chair of the Board
​​
Annual service as Chair of the Board of Directors
​​$30,000
Under our amended non-employee director compensation policy,Amended & Restated Non-employee Director Compensation Policy, upon initial election to our boardBoard of directors,Directors, each non-employee director will be granted an option to purchase 29,20035,040 shares of our common stock, referred to herein as the Initial Grant. Furthermore, our amended policyAmended & Restated Non-employee Director Compensation Policy provides that, on the date of each of our annual meeting of stockholders, each non-employee director who will continue as a non-employee director following such meeting will be granted an annual option to purchase 13,41917,520 shares of our common stock, referred to herein as the Annual Award. Each Annual Award vests in full on the earlier of (i) the first anniversary of the grant date or (ii) our next annual meeting of stockholders, subject to such director’s continued service to us through the applicable vesting date, unless otherwise determined by our boardBoard of directors.Directors. The Initial Grants vest in equal annual installments over three years from the date of grant, subject to such director’s continued service to us through the applicable vesting dates. Such awards are subject to full accelerated vesting upon the sale of the Company, subject to such director’s continued service to us through the date of such sale. In addition, aggregate amount of cash and equity compensation paid to any non-employee director in a calendar year may not exceed $1,000,000 for the first year of service, and $750,000 for each year of service thereafter (or such other limits as may be set forth in theour 2021 Stock Option and Incentive Plan, or 2021 Plan or any similar provision of a successor plan). The above-described cash retainers are paid quarterly in arrears, pro-rated based on the number of actual days served by the director during such calendar quarter. No additional compensation is paid for attending individual meetings of the boardBoard of directors.Directors. Employee directors receive no additional compensation for their service as a director. We reimburse all reasonable out-of-pocket expenses incurred by directors for their attendance at meetings of our boardBoard of directorsDirectors or any committee thereof.
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In December 2022, the Compensation Committee recommended, and the Board approved, pursuant to recommendations from Aon Radford, based on benchmarking against peer companies, an amended and restated non-employee director compensation policy, which became effective on December 15, 2022. Under that amended and restated policy, the Initial Grant was increased to an option to purchase 35,040 shares of our common stock upon initial election to our board of directors, and the Annual Award was increased to an option to purchase 17,520 shares of our common stock.

EXECUTIVE OFFICERS

The following table identifies our executive officers, and sets forth their current positions at Ikena Oncology, Inc., and their ages as of March 31, 2023.

Name

  Position Held with Ikena Oncology, Inc.  Officer
Since		   Age 

Mark Manfredi, Ph.D.

  President, Chief Executive Officer and Director   2017    52 

Jeffrey Ecsedy, Ph.D.

  Chief Development Officer   2019    53 

Sergio Santillana, M.D., M.Sc., MBA

  Chief Medical Officer   2020    60 

Jotin Marango, M.D., Ph.D.

  Chief Financial Officer and Head of Corporate
Development		   2022    44 

Michelle Zhang, Ph.D.

  Chief Scientific Officer   2019    53 

April 1, 2024.

Name​​Position Held with Ikena Oncology, Inc.​​
Officer
Since
​​Age
Mark Manfredi, Ph.D.
​​President, Chief Executive Officer and Director​​2017​​53
Jeffrey Ecsedy, Ph.D.
​​Chief Development Officer​​2019​​54
Jotin Marango, M.D., Ph.D.
​​Chief Financial Officer and Head of Corporate Development​​2022​​45
Caroline Germa, M.D.
​​Chief Medical Officer​​2024​​52
You should refer to “Class III Directors” above for information about our Chief Executive Officer and President, Mark Manfredi, Ph.D. Biographical information for our other executive officers is set forth below.

Jeffrey Ecsedy, Ph.D. has served as our Chief Development Officer since December 2021. Prior to that, Dr. Ecsedy served as our Chief Scientific Officer from March 2019 to December 2021. Prior to this, Dr. Ecsedy served as our Senior Vice President of Research and Development from October 2017 to February 2019. Prior to joining Ikena, from June 2013 to October 2017, Dr. Ecsedy served as the Senior Directorsenior director and Headhead of Oncology Translational Medicine at Takeda Pharmaceuticals Company Limited.Limited (NYSE: TAK). Dr. Ecsedy holds a Bachelor of Science in Biological Sciences from the University of Connecticut and a Doctorate of Philosophy from Boston College. We believe that Dr. Ecsedy is qualified to serve as our Chief Development Officer because of his significant scientific, drug discovery, clinical development and industry knowledge, and his long tenure in senior management roles.

Sergio Santillana, M.D., M.Sc., MBA has served as our Chief Medical Officer since July 2020. Prior to this, he served as Senior Clinical Consultant for Ikena from September 2019 to June 2020. Dr. Santillana is also founder and President of his own oncology consulting firm, SLSS Consulting LLC, where he provides strategic consultancy services since April 2019. From June 2017 to April 2019 Dr. Santillana served as Senior Vice President and Chief Medical Officer at Merrimack Pharmaceuticals, Inc., a company focused on developing biologics and nanotherapeutics for solid tumors. Before joining Merrimack Pharmaceuticals, Inc., from March 2016 to June 2017, he was Head of Clinical Research and then Chief Medical Officer for ARIAD Pharmaceuticals, a commercial-stage biotechnology company focused on developing targeted therapies for cancer, that was acquired by Takeda Pharmaceutical Company. From August 2014 to March 2016, Dr. Santillana served as the Senior Medical Director of Oncology and Clinical Research at Takeda Pharmaceuticals International Limited, where he was the Global Clinical Lead of early development programs. Prior to joining Takeda Oncology, he served in various oncology clinical development roles at GlaxoSmithKline and Eli Lilly Oncology. Before joining the biopharmaceutical industry, Dr. Santillana was a practicing medical oncologist for more than a decade. Dr. Santillana holds a Bachelor of Science, Medical Degree (MD) and specialty/residence in Medical Oncology from the Universidad Nacional Federico Villarreal, a Master of Science on Experimental Therapeutics from Kellogg College at Oxford University, and a Master of Business Administration from Sloan School of Management at the Massachusetts Institute of Technology. We believe that Dr. Santillana is qualified to serve as our Chief Medical Officer because of his executive experience in the life sciences industry and his extensive medical knowledge.

Jotin Marango, M.D., Ph.D. has served as our Chief Financial Officer and Head of Corporate Development since April 2022. Prior to this, he served as Senior Vice President, Chief Business Officersenior vice president, chief business officer at Aptose Biosciences Inc. (NASDAQ:(Nasdaq: APTO) from June 2019 to April 2022 and also as their Chief Financial Officerchief financial officer from May 2021 to April 2022. Before that, from September 2017 to April 2019, Dr. Marango worked as an equity research analyst at Roth Capital Partners covering small and mid-cap biotechnology companies focused on hematology,

oncology and rare diseases. Dr. Marango also served as Chief Operating Officerchief operating officer at the Samuel Waxman Cancer Research Foundation from 2012 to 2015, where he oversaw venture philanthropy initiatives in therapeutic development. Through his education and career, Dr. Marango has solidified a passion for working in oncology and facilitating growth for businesses looking to make a difference in cancer research. Dr. Marango holds a B.A. in Chemistry with Honors from Harvard University and earned his M.D. and Ph.D. from the Mount Sinai School of Medicine of New York University. We believe that Dr. Marango is qualified to serve as our Chief Financial Officer and Head of Corporate Development because of his extensive experience in oncology biopharma business, finance, and corporate relations & development.

Michelle Zhang, Ph.D.

Caroline Germa, M.D. has served as our Chief ScientificMedical Officer since November 2021.February 2024. Prior to this, Dr. ZhangGerma served as our Senior Vice President, Translational Researchthe executive vice president of the Global Medicine Development and Early Developmentchief medical officer at Transcenta Therapeutics, or Transcenta, from August 2022 to February 2024, where she played a pivotal role in shaping strategic goals for Transcenta’s oncology and non-oncology portfolio, ensuring successful execution across all clinical development functions. Before Transcenta, Dr. Germa worked as a consultant from September 2021 to August 2022 in the pharmaceutical industry. Dr. Germa has held senior leadership positions at global pharmaceutical companies such as AstraZeneca, where she served as vice president and head of clinical of Early Oncology from July 2019 to November 2021. Prior to that, Dr. ZhangSeptember 2021, and Bristol Myers Squibb, where she served as our Vice President, Researchvice president and Developmentdevelopment team lead from April 20162018 to SeptemberJuly 2019. Dr. Zhang holdsGerma earned her M.D. and board certification in medical oncology at the University of Lille, a Bachelordegree in immunology from the University of Science in Biology from Fudan UniversityLille and a Doctorate of Philosophydegree in Biochemistryhealth economics from Harvard University.Paris Diderot University in France. We believe that Dr. ZhangGerma is qualified to serve as our Chief ScientificMedical Officer because of her executive experience in the life sciences industry and her extensive industry knowledge and experience.

medical knowledge.

The principal occupation and employment during the past five years of each of our executive officers was carried on, in each case except as specifically identified above, with a corporation or organization that is not a parent, subsidiary or other affiliate of us. There is no arrangement or understanding between any of our executive officers and any other person or persons pursuant to which he or she was or is to be selected as an executive officer.

There are no material legal proceedings to which any of our executive officers is a party adverse to us or in which any such person has a material interest adverse to us.
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EXECUTIVE COMPENSATION

Our named executive officers for the year ended December 31, 20222023 are:

Mark Manfredi, Ph.D., our President and Chief Executive Officer;

Jotin Marango, M.D., Ph.D., our Chief Financial Officer and Head of Corporate Development; and

Sergio Santillana, M.D., M.Sc., MBA, our former Chief Medical Officer.

2022

2023 Summary Compensation Table

The following table presents the compensation awarded to, earned by or paid to each of our named executive officers for the years indicated.

   Year   Salary
($)		   Bonus
($)(1)		   Option
Awards
($)(2)		   All Other
Compensation
($)(3)		   Total
($)		 

Mark Manfredi, Ph.D.

   2022    546,000    245,700    1,660,355    12,200    2,464,255 

President and Chief Executive Officer

   2021    530,000    265,000    4,654,179    —      5,449,179 

Jotin Marango, M.D., Ph.D

   2022    291,506    156,400    1,708,234    —      2,156,140 

Chief Financial Officer and Head of Corporate Development (4)

            

Sergio Santillana, M.D., M.Sc., MBA

   2022    453,200    166,778    573,999    12,200    1,206,177 

Chief Medical Officer

   2021    440,000    176,000    1,096,022    —      1,712,022 

 ​​Year​​
Salary
($)
​​
Bonus
($)(1)
​​
Option Awards
($)(2)
​​
All Other
Compensation
($)(3)
​​
Total
($)
Mark Manfredi, Ph.D.
President and Chief Executive Officer
​​2023​​569,000​​227,600​​429,946​​14,094​​1,239,746
​2022​​546,000​​245,700​​1,660,355​​12,200​​2,464,255
Jotin Marango, M.D., Ph.D.(4)
Chief Financial Officer and Head of Corporate Development
​​2023​​431,400​​144,951​​205,202​​769​​781,553
​2022​​291,506​​156,400​​1,708,234​​—​​2,156,140
Sergio Santillana, M.D., M.Sc., MBA(5)
Chief Medical Officer
​​2023​​466,800​​147,509​​205,202​​14,031​​832,711
​2022​​453,200​​166,778​​573,999​​12,200​​1,206,177
(1)

Amounts represent bonuses earned in 20222023 and 20212022 and paid in 20232024 and 2022,2023, respectively, pursuant to the Company’s cash incentive plan based on the achievement of certain corporate and individual performance milestones.

(2)

The amounts reported represent the aggregate grant date fair value of the stock option awards granted to the named executive officers during fiscal year 20222023 and 2021,2022, calculated in accordance with ASC Topic 718. Such grant date fair values do not take into account any estimated forfeitures. The assumptions used in calculating the grant date fair values of the awards reported in this column are set forth in notes to consolidated financial statements included in our Annual Report on Form 10-K. The amounts reported in this column reflect the accounting cost for the stock options and does not correspond to the actual economic value that may be received upon exercise of the stock option or any sale of any of the underlying shares of common stock.

(3)

Amounts represent the Company’s matching contributions under its 401(k) plan.

plan and life insurance premiums paid.
(4)

Dr. Marango commenced employment on April 25, 2022, and his annual base salary was pro-rated accordingly for 2022. Dr. Marango was not an NEO in 2021 and therefore, no compensation data is shown for that year. Dr. Marango’s target bonus was not pro-rated, consistent with the terms of his employment agreement.

(5)
Dr. Santillana resigned as our Chief Medical Officer effective as of February 29, 2024.

Narrative to 20222023 Summary Compensation Table

Base salaries

Our named executive officers each receive a base salary to compensate them for services rendered to our company. The base salary payable to each named executive officer is intended to provide a fixed component of compensation reflecting the executive’s skill set, experience, role and responsibilities. Base salaries are reviewed annually, typically in connection with our annual performance review process, approved by our boardBoard of directorsDirectors or the compensation committee,Compensation Committee, and may be adjusted from time to time to realign salaries with market levels after taking into account individual responsibilities, performance, and experience.

For fiscal year 2022,2023, the annual base salary for each of Dr. Manfredi, Dr. Marango and Dr. Santillana were $546,000, $425,000$569,000, $431,400 and $453,200,$466,800, respectively. At the Compensation Committee and subsequent Board of

Directors meetingsmeeting in December 2022,January 2024, a salary increases,increase, effective as of January 1, 2023, were2024, was approved for Dr. Manfredi, Dr. Marango and Dr. Santillana in the amountsamount of $569,000, $431,400, and $466,800, respectively,$444,400 in connection with our annual performance review process.

Bonuses

For the fiscal year 2022,2023, each named executive officer was eligible to earn an annual cash bonus based on the achievement of certain corporate and individual performance milestones. The target annual bonus for each of Dr. Manfredi, Dr. Marango and Dr. Santillana, for the fiscal year ended December 31, 20222023 were 50%, 40%, and 40% of annual base salary, respectively.
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Equity Compensation

Our equity grant program is intended to align the interests of our named executive officers with those of our stockholders and to motivate them to make important contributions to our performance. In 2022,2023, we granted stock options to each of our named executive officers, as reflected in the “Outstanding Equity Awards at 20222023 Fiscal Year End Table” below, which were awardedapproved at the FebruaryDecember 2022 Compensation Committee and Board of Directors meetings.meetings with a January 2023 grant date. The vesting commencement date applicable to the stock options is January 1, 2022,2023, and the options will vest twenty-five percent (25%) on the first anniversary of the vesting commencement date, with the remaining shares vesting in equal monthly installments over the next three (3) years. The exercise price applicable to these awards was determined using the fair market value of the Company’s common stock on the date of approval. These grants are subject to our 2021 Stock Plan.

Perquisites

We generally do not provide perquisites to our executive officers, including our named executive officers.

Ikena Oncology, Inc. 401(k) Plan

We maintain a 401(k) retirement savings plan for our employees, including our named executive officers, who satisfy certain eligibility requirements. We make a 401(k) employer matching contribution of 4% of an employee’s elective deferral up to 6% of the employees eligible compensation up to a maximum matching contribution of $12,200$13,200 per year. Our named executive officers are eligible to participate in the 401(k) plan on the same terms as other full-time employees. Our 401(k) plan is intended to qualify for favorable tax treatment under Section 401(a) of the Internal Revenue Code of 1986, as amended, or the Code, and contains a cash or deferred feature that is intended to meet the requirements of Section 401(k) of the Code. We believe that providing a vehicle for tax-deferred retirement savings though our 401(k) plan adds to the overall desirability of our executive compensation package and further incentivizes our employees, including our named executive officers, in accordance with our compensation policies.

Executive Employment Arrangements

In March 2021, we entered into new employment agreements with each of Dr. Manfredi and Dr. Santillana, which superseded each such named executive officer’s existing offer letter, change in control and severance agreement and change in control severance agreement, as applicable, and which became effective upon our initial public offering. The new employment agreements contain substantially similar terms that provide for each of the named executive officer’s continued employment and annual base salary andas well as set forth the terms of their discretionary annual bonus, the at-will nature of their employment, certain expense reimbursements, the terms of severance payments payable upon certain terminations of employment and their eligibility to participate in our benefit plans generally.

In the event that Dr. Manfredi’s or Dr. Santillana’s service with the Company is terminated without “cause” or for “good reason” (in each case, as defined in his employment agreement), on or within twelve months after the

closing of a “change in control” (as defined in his employment agreement), such named executive officer will be entitled to the following severance benefits, subject to the executive executing a separation agreement and it becoming effective, (i) a lump-sum payment equal to equal to 1 times (or in the case of Dr. Manfredi, 1.5 times) the sum of (a) such named executive officer’s then-current base salary or the base salary in effect immediately prior to the change in control, if higher, plus (b) such named executive officer’s annual target bonus for the then-current year; (iii) immediate acceleration of all time-based stock options and other stock-based awards subject to time-based vesting held by such named executive officer, effective as of the later of the date of termination or the effective date of the separation agreement and release; and (iv) up to 12 months (or in the case of Dr. Manfredi, 18 months) of the employer portion of COBRA premium payments.

In the event that Dr. Manfredi’s or Dr. Santillana’s service with the Company is terminated without “cause” or for “good reason,” in each case, other than in connection with a change in control, such named executive officer will be entitled to the following severance benefits, subject to such executive executing a separation agreement and release and it becoming effective: (i) payments equal to nine months of such named executive officer’s then-current base salary (or in the case of Dr. Manfredi, 12 months) and (ii) up to nine months (or in the case of Dr. Manfredi, 12 months) of the employer portion of COBRA premium payments.
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Upon the occurrence of a change of control, all payments and benefits received by Dr. Manfredi and Dr. Santillana in connection with a change of control that constitute “excess parachute payments” under Section 280G of the Code will be subject to a modified economic cutback treatment such that the “excess parachute payments” to be received by each such affected named executive officer will either be (i) paid in full or (ii) reduced below such named executive officer’s threshold amount under Code Section 280G in order to avoid triggering the excise tax that would otherwise be payable on such “excess parachute payment” amounts.

On April 25, 2022, we entered into an employment agreement with Dr. Marango, or the Marango employment agreement, which provides for an initial annual base salary of $425,000 and sets forth the terms of his annual bonus eligibility, with a target amount of 40% of his base salary, certain expense reimbursements, the terms of severance payments payable upon certain terminations of employment and his eligibility to participate in our benefit plans generally. In addition, the Marango employment agreement entitles Dr. Marango to receive an option to purchase 397,199 shares of the Company’s common stock, at an exercise price equal to the fair market value of such shares on the date of grant, twenty-five percent of which will vest and become exercisable on the one-year anniversary of April 25, 2022 (which was Dr. Marango’s start date), and the balance of which will vest in equal installments over the next thirty-six months thereafter, subject to Dr. Marango’s continued employment.

In the event that Dr. Marango’s service with the Company is terminated without “cause” or for “good reason,” in each case, other than in connection with a change in control, Dr. Marango will be entitled to the following severance benefits, subject to his executing a separation agreement and release and it becoming effective: (i) a lump-sum payment equal to nine months of Dr. Marango’s then-current base salary plus the target incentive compensation established for Dr. Marango in the fiscal year of termination and (ii) up to nine months of COBRA premium reimbursements.

In the event that Dr. Marango’s service with the Company is terminated “without cause” or for “good reason” (in each case, as defined in his employment agreement), on or within forty-five (45) days preceding or twelve months after the closing of a “change in control” (as defined in his employment agreement), Dr. Marango will be entitled to the following severance benefits, subject to his executing a separation agreement and it becoming effective, (i) a lump-sum payment equal to equal to one times of Dr. Marango’s then-current base salary or the base salary in effect immediately prior to the change in control, if higher, (ii) a lump-sum payment in an amount equal to one times of Dr. Marango’s annual target bonus for the then-current year or the target bonus in effect immediately prior to the change in control, if higher; and (iii) subject to Dr. Marango’s copayment of premium amounts at the applicable active employees’ rate and proper COBRA election, up to twelve months of the employer portion of COBRA premium payments.

Upon the occurrence of a change of control, all payments and benefits received by Dr. Marango in connection with a change of control that constitute “excess parachute payments” under Section 280G of the Code will be subject to a modified economic cutback treatment such that the “excess parachute payments” to be received by Dr. Marango will either be (i) paid in full or (ii) reduced below such named executive officer’s threshold amount under Section 280G of the Code in order to avoid triggering the excise tax that would otherwise be payable on such “excess parachute payment” amounts.

In addition, each of our named executive officers entered into our standard confidential information, non-competition, non-solicitation, and invention assignment agreement with us which continues to remain in effect and contains protections of confidential information, requires the assignment of inventions and contains other restrictive covenants.

Compensation Risk Assessment

We believe that although a portion of the compensation provided to our executive officers and other employees is performance-based, our executive compensation program does not encourage excessive or unnecessary risk taking. This is primarily due to the fact that our compensation programs are designed to encourage our executive officers and other employees to remain focused on both short-term and long-term strategic goals, in particular in connection with our pay-for-performance compensation philosophy. As a result, we do not believe that our compensation programs are reasonably likely to have a material adverse effect on us.
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Outstanding Equity Awards at Fiscal 2022 2023 Year-End

The following table sets forth information regarding outstanding equity awards held by our named executive officers as of fiscal year 2022:

  OPTION AWARDS (1) 
NAME Vesting
Commencement
Date		  Number of
Securities
Underlying
Unexercised
Options
Exercisable
(2)		  Number of
Securities
Underlying
Unexercised
Options
Unexercisable
(2)		  Option Exercise
Price
($)		  Option
Expiration
Date		 

Mark Manfredi, Ph.D.

  —     95,305   —     1.15   8/23/2026 
  —     158,843   —     2.93   2/19/2028 
  —     151,279   —     2.15   12/17/2028 
  3/20/2019   191,744   12,785   4.15   3/19/2029 
  2/12/2021   425,966   503,420   7.87   2/11/2031 
  1/1/2022   —     283,900   9.76   2/2/2032 

Jotin Marango, M.D., Ph.D.

  4/25/2022   —     397,199   5.88   4/24/2032 

Sergio Santillana, M.D., M.Sc., MBA

  7/23/2020   95,276   62,435   4.51   7/22/2030 
  2/12/2021   100,305   118,557   7.87   2/11/2031 
  1/1/2022   —     70,400   11.45   2/1/2032 

2023:
 ​​
Option Awards(1)
Name​​
Vesting
Commencement
Date
​​
Number of
Securities
Underlying
Unexercised
Options
Exercisable(2)
​​
Number of
Securities
Underlying
Unexercised
Options
Unexercisable(2)
​​
Option
Exercise
Price
($)
​​
Option
Expiration
Date
Mark Manfredi, Ph.D.
​​—​​95,305​​—​​1.15​​8/23/2026
​​—​​158,843​​—​​2.93​​2/19/2028
 ​​—​​151,279​​—​​2.15​​12/17/2028
​​3/20/2019​​204,529​​—​​4.15​​3/19/2029
 ​​2/12/2021​​658,310​​271,076​​7.87​​2/11/2031
​​1/1/2022​​114,472​​124,428​​9.76​​2/2/2032
 ​​1/1/2023​​—​​220,000​​2.62​​1/2/2033
Jotin Marango, M.D., Ph.D.
​​4/25/2022​​165,499​​231,700​​5.88​​4/24/2032
​​1/1/2023​​—​​105,000​​2.62​​1/2/2033
Sergio Santillana, M.D., M.Sc., MBA​​7/23/2020​​134,708​​23,003​​4.51​​7/22/2030
 ​​2/12/2021​​155,022​​63,840​​7.87​​2/11/2031
​​1/1/2022​​33,733​​36,667​​11.45​​2/1/2032
 ​​1/1/2023​​—​​105,000​​2.62​​1/2/2033
(1)

Each of the outstanding equity awards in the table above that was granted prior to our initial public offering in March 2021 was granted pursuant to our 2016 Stock Incentive Plan, as amended, or the 2016 Plan. Each of the outstanding equity awards listed in the table above is subject to accelerated vesting in the event of certain terminations following a change in control, as described above in the “Executive Employment Arrangements” section.

(2)

All options in the table above vest as follows: 25% of the total shares underlying the option vest on the first anniversary date of the vesting commencement date and the remainder vest over the next three years in equal monthly installments on the last day of each succeeding calendar month (with the option becoming fully vested on the fourth anniversary of the vesting commencement date), subject to continued service to us through the applicable vesting date.

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Equity Compensation Plan Information

The following table provides information as of December 31, 20222023 with respect to the shares of our common stock that may be issued under our existing equity compensation plans.

   Equity Compensation Plan Information 
Plan Category  Number of
securities
to be issued
upon exercise of
outstanding
options,
warrants
and rights		  Weighted
average
exercise
price of
outstanding
options,
warrants
and rights		   Number of
securities
remaining
available
for future
issuance
under equity
compensation
plans
(excluding
securities in
first column)		 

Equity compensation plans approved by security holders(1)

   6,589,479(2)   7.29    2,986,528(3)(4) 

Equity compensation plans not approved by security holders

   —     —      —   
  

 

 

  

 

 

   

 

 

 

Total

   6,589,479   7.29    2,986,528 
  

 

 

  

 

 

   

 

 

 

 ​​Equity Compensation Plan Information
Plan Category​​
Number of
securities to be
issued upon
exercise of
outstanding
options, warrants
and rights
​​
Weighted
average
exercise price of
outstanding
options, warrants
and rights
​​
Number of securities
remaining available
for future issuance
under equity
compensation plans
(excluding securities
in first column)
Equity compensation plans approved by security holders(1)
​​
7,088,261(2)
​​6.35​​
3,759,868(3)(4)
Equity compensation plans not approved by security holders
​​—​​—​​—
Total
​​7,088,261​​6.35​​3,759,868
(1)

Includes the following plans: our 2016 Stock Incentive Plan, or 2016 Plan, our 2021 Plan, and our 2021 Employee Stock Purchase Plan, or ESPP.

(2)

There are currently no outstanding purchase rights under our ESPP.

(3)

Consists of shares available for future issuance under the 2021 Plan and the ESPP. As of December 31, 2022,2023, a total of 2,639,9153,413,255 shares of our common were available for issuance pursuant to the 2021 Plan. As of December 31, 2022,2023, a total of 346,613 shares of our common stock were available for issuance pursuant to the ESPP.

(4)

The 2021 Plan provides that the number of shares reserved and available for issuance under the plan will automatically increase each January 1, beginning on January 1, 2022, by 4% of the outstanding number of shares of our common stock on the immediately preceding December 31 or such lesser number of shares as determined by the Compensation Committee. The shares of common stock underlying any awards that are forfeited, cancelled, held back upon exercise or settlement of an award to satisfy the exercise price or tax withholding, reacquired by us prior to vesting, satisfied without the issuance of stock, expire or are otherwise terminated, other than by exercise, under the 2021 Plan and the 2016 Plan will be added back to the shares of common stock available for issuance under the 2021 Plan. Following our initial public offering, the Company no longer makes grants under the 2016 Plan.

The ESPP provides that the number of shares reserved and available for issuance under the plan will automatically increase each January 1, beginning on January 1, 2021, by the lesser of (i) 346,613 shares of our common stock, (ii) 1% of the outstanding number of shares of our common stock on the immediately preceding December 31 or (iii) such lesser number of shares as determined by the Compensation Committee. This number will be subject to adjustment in the event of a stock split, stock dividend or other change in our capitalization. The Compensation Committee determined not to increase the shares on January 1, 20222023 and 2023,2024, respectively.
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CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS

Certain Relationships and Transactions

Other than the compensation agreements and other arrangements described under “Executive Compensation” and “Non-Employee“Non-Employee Director Compensation Policy” in this proxy statement and the transactions described below, since January 1, 2021,2022, there has not been and there is not currently proposed, any transaction or series of similar transactions to which we were, or will be, a party in which the amount involved exceeded, or will exceed, $120,000 (or, if less, 1% of the average of our total assets amounts at December 31, 20212022 and 2022)2023) and in which any director, executive officer, holder of five percent or more of any class of our capital stock or any member of the immediate family of, or entities affiliated with, any of the foregoing persons, had, or will have, a direct or indirect material interest.

Initial Public Offering

2023 Acquisition
In March 2021,August 2023, we acquired Pionyr Immunotherapeutics, Inc., or Pionyr, in connectionaccordance with our initial public offering,the terms of the Agreement and Plan of Merger, or the Merger Agreement, dated August 4, 2023, or the 2023 Acquisition. Under the terms of the Merger Agreement, at the closing of the 2023 Acquisition, we sold an aggregateacquired all of 8,984,375Pionyr’s assets, including approximately $48.0 million in net cash at the time of closing, and we issued the holders of Pionyr common stock a total of 1,800,652 shares of the our common stock including(including 153,121 shares of our non-voting common stock) at the exercise in full bypurchase price of $7.15 per share and 4,153,439 shares of Series A Preferred Stock, also at the underwriterspurchase price of their option to purchase up to 1,171,875 additional shares$7.15 per share, each share of which was subsequently converted into one share of the our common stock at a public offering pricespecial meeting of $16.00 per share. The aggregate gross proceeds to us fromstockholders on October 11, 2023, or the offering were approximately $143.8 million, before deducting underwriting discounts and commissions and other offering expenses. The following table summarizes purchases2023 Special Meeting.
OrbiMed Advisors LLC, a five percent holder of our common stock and a related party of our company, was previously a stockholder of Pionyr. In connection with the 2023 Acquisition, OrbiMed was allocated 153,121 shares of non-voting common stock by related persons in connection withand 353,192 shares of Series A Preferred Stock, which converted to shares of our initial public offering:

STOCKHOLDER  SHARES
OF
COMMON
STOCK		   TOTAL
PURCHASE
PRICE		 

OrbiMed Private Investments VI, LP(1)

   375,000   $6,000,000 

OrbiMed Genesis Master Fund, L.P.(2)

   48,400   $774,400 

Omega Fund VI, L.P.(3)

   450,000   $7,200,000 

(1)

The securities are held of record by OrbiMed Private Investments VI, LP (“OPI VI”). OrbiMed Capital GP VI LLC (“GP VI”) is the general partner of OPI VI. OrbiMed Advisors LLC (“OrbiMed Advisors”), a registered investment adviser under the Investment Advisers Act of 1940, as amended, is the managing member of GP VI. By virtue of such relationships, OrbiMed Advisors and GP VI may be deemed to have voting power and investment power over the securities held by OPI VI and as a result, may be deemed to have beneficial ownership over such securities. OrbiMed Advisors exercises voting and investment power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the shares held by OPI VI.

(2)

The securities are held of record by OrbiMed Genesis Master Fund, L.P. (“OrbiMed Genesis”). OrbiMed Genesis GP LLC (“OrbiMed Genesis GP”) is the general partner of OrbiMed Genesis. OrbiMed Advisors is the managing member of OrbiMed Genesis GP. By virtue of such relationships, OrbiMed Advisors and OrbiMed Genesis GP may be deemed to have voting power and investment power over the securities held by Genesis and as a result, may be deemed to have beneficial ownership over such securities. OrbiMed Advisors exercises voting and investment power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the shares held by OrbiMed Genesis.

(3)

Shares held directly by Omega Fund VI, L.P. (“Omega VI”). Omega Fund VI GP, L.P. (“Omega VI GP”) is the sole general partner of Omega VI. Omega Fund VI GP Manager, Ltd. (“Omega VI Manager”) is the sole general partner of Omega VI GP. The Reporting Person is a director of Omega VI Manager and disclaims beneficial ownership of the shares held by Omega VI except to the extent of his pecuniary interest therein, if any.

common stock pursuant to stockholder approval at the 2023 Special Meeting.

Agreements with Stockholders

In connection with our Series B convertible preferred stock financing, we entered into investors’ rights, voting and right of first refusal and co-sale agreements containing registration rights, information rights, voting rights and rights of first refusal, among other things, with certain holders of our preferred stock and certain holders of our common stock. These stockholder agreements terminated upon the closing of our initial public offering in March 2021, except for the registration rights granted under our investors’ rights agreement, as more fully described in our Description of Securities, filed as Exhibit 4.3 to our Annual Report on Form 10-K, filed March 17, 2022.

Indemnification Agreements

In connection with our initial public offering in March 2021, we entered into agreements to indemnify our directors and executive officers. These agreements, among other things, require us to indemnify these individuals for certain expenses (including attorneys’ fees), judgments, fines and settlement amounts reasonably incurred by such person in any action or proceeding, including any action by or in our right, on account of any services undertaken by such person on our behalf or that person’s status as a member of our boardBoard of directorsDirectors to the maximum extent allowed under Delaware law.

Policies for Approval of Related Party Transactions

Our boardBoard of directorsDirectors reviews and approves transactions with directors, officers and holders of five percent or more of our voting securities and their affiliates, each a related party. Prior to our initial public offering in March 2021, the material facts as to the related party’s relationship or interest in the transaction were disclosed to our boardBoard of directorsDirectors prior to their consideration of such transaction, and the transaction was not considered approved by our boardBoard of directorsDirectors unless a majority of the directors who are not interested in the transaction approved the transaction. Further, when stockholders are entitled to vote on a transaction with a related party, the material facts of the related party’s relationship or interest in the transaction were disclosed to the stockholders, who must approve the transaction in good faith.
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In connection with our initial public offering in March 2021, we adopted a written related party transactions policy that provides that such transactions must be approved by our audit committee.Audit Committee. This policy became effective on the date on which the registration statement related to our initial public offering was declared effective by the SEC. Pursuant to this policy, the audit committeeAudit Committee has the primary responsibility for reviewing and approving or disapproving “related party transactions,” which are transactions between us and related persons in which the aggregate amount involved exceeds or may be expected to exceed $120,000 and in which a related person has or will have a direct or indirect material interest. For purposes of this policy, a related person will be defined as a director, executive officer, nominee for director or greater than 5% beneficial owner of our common stock, in each case since the beginning of the most recently completed year, and their immediate family members.
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PRINCIPAL STOCKHOLDERS

The following table sets forth information, to the extent known by us or ascertainable from public filings, with respect to the beneficial ownership of our common stock as of March 31, 2023April 1, 2024 by:

each of our directors;

each of our named executive officers;

all of our current directors and executive officers as a group; and

each person, or group of affiliated persons, who is known by us to beneficially own greater-than-5.0%greater than 5.0% of our common stock.

The column entitled “Percentage of Voting Shares” under “Shares Beneficially Owned” below is based on a total of 36,257,49341,889,525 voting shares of our common stock outstanding as of March 31, 2023.

April 1, 2024, and excludes 6,368,586 non-voting shares of our common stock outstanding on that date. As of April 1, 2024, all outstanding non-voting shares of our common stock were beneficially owned by entities affiliated with OrbiMed Advisors LLC.

Beneficial ownership is determined in accordance with the rules and regulations of the SEC and includes voting or investment power with respect to our common stock. Shares of our common stock subject to options that are currently exercisable or exercisable within 60 days of March 31, 2023April 1, 2024 are considered outstanding and beneficially owned by the person holding the options for the purpose of calculating the percentage ownership of that person but not for the purpose of calculating the percentage ownership of any other person. Except as otherwise noted, the persons and entities in this table have sole voting and investing power with respect to all of the shares of our common stock beneficially owned by them, subject to community property laws, where applicable. Except as otherwise indicated in the table below, addresses of named beneficial owners are in care of Ikena Oncology, Inc., 645 Summer Street, Suite 101, Boston, Massachusetts 02210.

  Shares beneficially owned 

Name and address of beneficial owner (1)

 Number of
Voting Shares		  Number of Non-
Voting Shares		  Percentage 

> 5% Stockholders:

   

Entities affiliated with OrbiMed Advisors LLC (2)

  3,186,166   6,215,466   25.93% 

Entities affiliated with Atlas Venture (3)

  5,018,178   —     13.84% 

Entities affiliated with Biotechnology Value Fund, L.P. (4)

  2,503,071    6.90% 

Entities affiliated with FMR LLC (5)

  3,724,575   —     10.27% 

Omega Fund VI, L.P. (6)

  2,249,123   —     6.20% 

Celgene Corporation (Bristol-Myers Squibb Company) (7)

  2,133,142    5.88% 

Entities affiliated with Citadel Advisors LLC (8)

  2,126,401    5.86% 

Named Executive Officers and Directors:

   

Mark Manfredi, Ph.D. (9)

  1,212,365   —     3.24% 

Jotin Marango, M.D., Ph.D. (10)

  107,574   —     * 

Sergio Santillana, M.D., M.Sc., MBA (11)

  258,274   —     * 

David Bonita, M.D. (2)

  4,751   —     * 

Iain D. Dukes, D.Phil. (12)

  239,252   —     * 

Jean-François Formela, M.D. (3)

  4,751   —     * 

Maria Koehler, M.D. (13)

  22,643   —     * 

Otello Stampacchia, Ph.D. (6)

  4,751   —     * 

Richard Wooster, Ph.D. (14)

  9,733   —     * 

Owen Hughes

  —      * 

All executive officers and directors as a group (12 persons) (15)

  2,398,486   —     6.21% 

Name and address of beneficial owner(1)
​​Shares beneficially owned
​
Number of
Voting Shares
​​
Number of
Non-Voting
Shares
​​
Percentage
of Voting
Shares
> 5% Stockholders:
​​ ​​ ​​ 
Entities affiliated with Atlas Venture(2)
​​5,018,178​​—​​11.98%
Entities affiliated with Biotechnology Value Fund, L.P.(3)
​​4,769,164​​—​​11.39%
Entities affiliated with OrbiMed Advisors LLC(4)
​​3,539,358​​6,368,586​​8.45%
Gilead Sciences, Inc.(5)
​​2,931,467​​—​​7.00%
Omega Fund VI, L.P.(6)
​​2,249,123​​—​​5.37%
Named Executive Officers and Directors:
​​ ​​ ​​ 
Mark Manfredi, Ph.D.(7)
​​1,577,766​​—​​3.63%
Jotin Marango, M.D., Ph.D.(8)
​​241,874​​—​​*
Sergio Santillana, M.D., M.Sc., MBA(9)
​​405,026​​—​​*
David P. Bonita, M.D.(10)
​​21,525​​—​​*
Iain D. Dukes, D.Phil.(11)
​​263,987​​—​​*
Jean-François Formela, M.D.(12)
​​21,525​​—​​*
Maria Koehler, M.D.(13)
​​48,363​​—​​*
Otello Stampacchia, Ph.D.(14)
​​21,525​​—​​*
Richard Wooster, Ph.D.(15)
​​32,885​​—​​*
Owen Hughes(16)
​​11,680​​—​​*
All current executive officers and directors as a group (11 persons)(17)
​​2,647,179​​—​​5.94%
*

Represents beneficial ownership of less than one percent.

(1)

Unless otherwise indicated, the address for each beneficial owner is c/o Ikena Oncology, Inc., 645 Summer Street, Suite 101, Boston, Massachusetts 02210.

(2)

Information herein is based on the Schedule 13D/A filed with the SEC on August 16, 2021 and the Form 4 filed with the SEC on June 22, 2022 by OrbiMed Advisors LLC (“OrbiMed Advisors”), OrbiMed Capital GP VI LLC (“OrbiMed GP”), OrbiMed Genesis GP LLC (“OrbiMed Genesis GP”), and OrbiMed Capital LLC (“OrbiMed Capital”) (collectively, the “Reporting Persons”). OrbiMed Private Investments VI, LP, (“OPI VI”) holds 2,098,097 shares of common stock and 5,429,023 shares of non-voting common stock. OrbiMed GP is the general partner of OPI VI, pursuant to the terms of the limited partnership agreement of OPI VI, and OrbiMed Advisors is the managing member of OrbiMed GP, pursuant to the terms of the limited liability company agreement of OrbiMed GP. As a result, OrbiMed Advisors and OrbiMed GP share power to direct the vote and disposition of the Shares held by OPI VI and may be deemed directly or indirectly, including by reason of their mutual affiliation, to be the beneficial owners of the Shares held by OPI VI. OrbiMed Advisors exercises this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the Shares held by OPI VI. OrbiMed Genesis Master Fund, L.P. (“OrbiMed Genesis”) holds 91,014 shares of common stock and 157,288 shares of non-voting common stock. OrbiMed Genesis GP is the general partner of OrbiMed Genesis, pursuant to the terms of the limited partnership agreement of OrbiMed Genesis, and OrbiMed Advisors is the managing member of OrbiMed Genesis GP, pursuant to the terms of the limited liability company agreement of OrbiMed Genesis GP. As a result, OrbiMed Advisors and OrbiMed Genesis GP share power to direct the vote and disposition of the Shares held by OrbiMed Genesis and may be deemed, directly or indirectly, including by reason of their mutual affiliation, to be the beneficial owners of the Shares held by OrbiMed Genesis. OrbiMed Advisors exercises this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the Shares held by OrbiMed Genesis. Worldwide Healthcare Trust PLC (“WWH”) holds 997,055 shares of common stock and 629,155 shares of non-voting common stock. OrbiMed Capital is the investment advisor of WWH. As a result, OrbiMed Capital has the power to direct the vote and disposition of the Shares held by WWH and may be deemed directly or indirectly, including by reason of mutual affiliation, to be the beneficial owner of the Shares held by WWH. OrbiMed Capital exercises this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the Shares held by WWH. The principal business address of these entities is c/o OrbiMed Advisors LLC, 601 Lexington Avenue 54th Floor, New York, NY 10022.

(3)

Information herein is based on the Schedule 13D filed with the SEC on February 11, 2022 by (i) Atlas Venture Fund X, L.P., a Delaware limited partnership (“Atlas X”), (ii) Atlas Venture Associates X, L.P., a Delaware limited partnership (“AVA X LP”), (iii) Atlas Venture Associates X, LLC, a Delaware limited liability company (“AVA X LLC” and together with Atlas X and AVA X LP, the “Fund X Reporting Persons”), (iv) Atlas Venture Fund XI, L.P., a Delaware limited partnership (“Atlas XI”), (v) Atlas Venture Associates XI, L.P., a Delaware limited partnership (“AVA XI LP”), (vi) Atlas Venture Associates XI, LLC, a Delaware limited liability company (“AVA XI LLC” and together with Atlas XI and AVA XI LP, the “Fund XI Reporting Persons”) (vii) Atlas Venture Opportunity Fund I, L.P., a Delaware limited partnership (“AVOF”), (viii) Atlas Venture Associates Opportunity I, L.P., a Delaware limited partnership (“AVAO LP”) and (ix) Atlas Venture Associates Opportunity I, LLC, a Delaware limited liability company (“AVAO LLC” and together with AVOF and AVAO LP, the “Opportunity Fund Reporting Persons” and together with the Fund X Reporting Persons and Fund XI Reporting Persons, the “Reporting Persons”). Atlas X is the record owner of 2,901,609 shares of common stock. AVA X LP is the general partner of Atlas X and AVA X LLC is the general partner of AVA X LP. Each of Atlas X, AVA X LP and AVA X LLC has shared voting and dispositive power over the shares held by Atlas X. As such, each of Atlas X, AVA X LP and AVA X LLC may be deemed to beneficially own the shares held by Atlas X. Atlas XI is the record owner of 1,241,935 shares of Common Stock. AVA XI LP is the general partner of Atlas XI and AVA XI LLC is the general partner of AVA XI LP. Each of Atlas XI, AVA XI LP and AVA XI LLC has shared voting and dispositive power over the shares held by Atlas XI. As such, each of Atlas XI, AVA XI LP and AVA XI

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company (“AVA XI LLC” and together with Atlas XI and AVA XI LP, the “Fund XI Reporting Persons”) (vii) Atlas Venture Opportunity Fund I, L.P., a Delaware limited partnership (“AVOF”), (viii) Atlas Venture Associates Opportunity I, L.P., a Delaware limited partnership (“AVAO LP”) and (ix) Atlas Venture Associates Opportunity I, LLC, a Delaware limited liability company (“AVAO LLC” and together with AVOF and AVAO LP, the “Opportunity Fund Reporting Persons” and together with the Fund X Reporting Persons and Fund XI Reporting Persons, the “Atlas Reporting Persons”). Atlas X is the record owner of 2,901,609 shares of common stock. AVA X LP is the general partner of Atlas X and AVA X LLC is the general partner of AVA X LP. Each of Atlas X, AVA X LP and AVA X LLC has shared voting and dispositive power over the shares held by Atlas X. As such, each of Atlas X, AVA X LP and AVA X LLC may be deemed to beneficially own the shares held by Atlas X. Atlas XI is the record owner of 1,241,935 shares of Common Stock. AVA XI LP is the general partner of Atlas XI and AVA XI LLC is the general partner of AVA XI LP. Each of Atlas XI, AVA XI LP and AVA XI LLC has shared voting and dispositive power over the shares held by Atlas XI. As such, each of Atlas XI, AVA XI LP and AVA XI LLC may be deemed to beneficially own the shares held by Atlas XI. AVOF is the record owner of 874,634 shares of Common Stock. AVAO LP is the general partner of AVOF and AVAO LLC is the general partner of AVAO LP. Each of AVOF, AVAO LP and AVAO LLC has shared voting and dispositive power over the shares held by AVOF. As such, each of AVOF, AVAO LP and AVAO LLC may be deemed to beneficially own the shares held by AVOF. The address of the principal place of business of each of the Atlas Reporting Persons is c/o 300 Technology Square, 8th Floor, Cambridge, Massachusetts 02139.
(3)
LLC may be deemed to beneficially own the shares held by Atlas XI. AVOF is the record owner of 874,634 shares of Common Stock. AVAO LP is the general partner of AVOF and AVAO LLC is the general partner of AVAO LP. Each of AVOF, AVAO LP and AVAO LLC has shared voting and dispositive power over the shares held by AVOF. As such, each of AVOF, AVAO LP and AVAO LLC may be deemed to beneficially own the shares held by AVOF. The address of the principal place of business of each of the Reporting Persons is c/o 300 Technology Square, 8th Floor, Cambridge, Massachusetts 02139.
(4)

Information herein is based on the Schedule 13G/A filed with the SEC on February 14, 20232024 by Biotechnology Value Fund, L.P. (“BVF”). Consists of (i) 1,358,5932,469,828 shares beneficially owned by BVF, (ii) 985,5011,983,612 shares beneficially owned by BVF2 and (iii) 130,823253,887 shares beneficially owned by Trading Fund OS. BVF GP, as the general partner of BVF, may be deemed to beneficially own the 1,358,5932,469,828 Shares beneficially owned by BVF. BVF2 GP, as the general partner of BVF2, may be deemed to beneficially own the 985,5011,983,612 Shares beneficially owned by BVF2. Partners OS, as the general partner of Trading Fund OS, may be deemed to beneficially own the 130,823253,887 Shares beneficially owned by Trading Fund OS. BVF GPH, as the sole member of each of BVF GP and BVF2 GP, may be deemed to beneficially own the 2,344,0944,453,440 Shares beneficially owned in the aggregate by BVF and BVF2. Partners, as the investment manager of BVF, BVF2 and Trading Fund OS, and the sole member of Partners OS, may be deemed to beneficially own the 2,503,0714,769,164 Shares beneficially owned in the aggregate by BVF, BVF2 and Trading Fund OS and held in a certain Partners managed account (the “Partners Managed Account”), including 28,15461,837 Shares held in the Partners Managed Account. BVF Inc., as the general partner of Partners, may be deemed to beneficially own the 2,503,0714,769,164 Shares beneficially owned by Partners. Mr. Lampert, as a director and officer of BVF Inc., may be deemed to beneficially own the 2,503,0714,769,164 Shares beneficially owned by BVF Inc. BVF GP disclaims beneficial ownership of the Shares beneficially owned by BVF. BVF2 GP disclaims beneficial ownership of the Shares beneficially owned by BVF2. Partners OS disclaims beneficial ownership of the Shares beneficially owned by Trading Fund OS. BVF GPH disclaims beneficial ownership of the Shares beneficially owned by BVF and BVF2. Each of Partners, BVF Inc. and Mr. Lampert disclaims beneficial ownership of the Shares beneficially owned by BVF, BVF2 and Trading Fund OS and held in the Partners Managed Account. The address of the principal business office of BVF, BVF GP, BVF2, BVF2 GP, BVF GPH, and Partners is 44 Montgomery St., 40th Floor, San Francisco, California 94104 and the address of the principal business office of Trading Fund OS and Partners OS is PO Box 309 Ugland House, Grand Cayman, KY1-1104, Cayman Islands.

(4)
Information herein is based on the Schedule 13D/A filed with the SEC on September 21, 2023 and the Form 4/A filed with the SEC on September 21, 2023 by OrbiMed Advisors LLC (“OrbiMed Advisors”), OrbiMed Capital GP VI LLC (“OrbiMed GP”), OrbiMed Genesis GP LLC (“OrbiMed Genesis GP”), and OrbiMed Capital LLC (“OrbiMed Capital”) (collectively, the “Reporting Persons”), except that the number of non-voting shares of common stock as disclosed on the Schedule 13D/A has been revised in the table above because it exceeds the number of non-voting shares outstanding by one share. OrbiMed Advisors has shared voting and dispositive power over 2,542,303 voting shares of common stock, comprised of: (a) 2,451,289 voting shares of common stock held by OrbiMed Private Investments VI, LP (“OPI VI”), of which 353,192 shares were acquired in connection with our acquisition of Pionyr, and over which OrbiMed GP has shared voting and dispositive power, and (b) 91,014 voting shares of common stock held by OrbiMed Genesis Master Fund, L.P. (“OrbiMed Genesis”), over which OrbiMed Genesis GP has shared voting and dispositive power. Worldwide Healthcare Trust PLC (“WWH”) holds 997,055 voting shares of common stock, which may be deemed to be beneficially owned by OrbiMed Capital. Additionally, OPI VI holds 5,582,144 shares of non-voting common stock, OrbiMed Genesis holds 157,288 shares of non-voting common stock, and WWH holds 629,155 shares of non-voting common stock. OrbiMed GP is the general partner of OPI VI, pursuant to the terms of the limited partnership agreement of OPI VI, and OrbiMed Advisors is the managing member of OrbiMed GP, pursuant to the terms of the limited liability company agreement of OrbiMed GP. As a result, OrbiMed Advisors and OrbiMed GP share power to direct the vote and disposition of the shares held by OPI VI and may be deemed directly or indirectly, including by reason of their mutual affiliation, to be the beneficial owners of the Shares held by OPI VI. OrbiMed Advisors exercises this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the Shares held by OPI VI. OrbiMed Genesis GP is the general partner of OrbiMed Genesis, pursuant to the terms of the limited partnership agreement of OrbiMed Genesis, and OrbiMed Advisors is the managing member of OrbiMed Genesis GP, pursuant to the terms of the limited liability company agreement of OrbiMed Genesis GP. As a result, OrbiMed Advisors and OrbiMed Genesis GP share power to direct the vote and disposition of the shares held by OrbiMed Genesis and may be deemed, directly or indirectly, including by reason of their mutual affiliation, to be the beneficial owners of the Shares held by OrbiMed Genesis. OrbiMed Advisors exercises this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the Shares held by OrbiMed Genesis. OrbiMed Capital is the investment advisor of WWH. As a result, OrbiMed Capital has the power to direct the vote and disposition of the Shares held by WWH and may be deemed directly or indirectly, including by reason of mutual affiliation, to be the beneficial owner of the Shares held by WWH. OrbiMed Capital exercises this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the Shares held by WWH. The principal business address of each of these entities and individuals is c/o OrbiMed Advisors LLC, 601 Lexington Avenue 54th Floor, New York, NY 10022.
(5)

Information herein based on the Schedule 13G filed with the SEC on October 19, 2023 by Gilead Sciences, Inc. (“Gilead”) with respect to 2,931,467 shares of common stock owned by Gilead. The address of the principal business office of Gilead is 333 Lakeside Drive, Foster City, California 94404.

(6)
Information herein is based on the Schedule 13G/A filed with the SEC on January 10, 2023 by FMR LLC. Fidelity Management & Research Company LLC, or FMR Co. LLC, beneficially own shares reported in this filing. FMR Co. LLC beneficially owns five percent or greater of the outstanding shares reported in this filing. Abigail P. Johnson is a Director, the Chairman, and the Chief Executive Officer of FMR LLC. Members of the Johnson family, including Abigail P. Johnson, are the predominant owners, directly or through trusts, of Series B voting common shares of FMR LLC, representing 49% of the voting power of FMR LLC. The Johnson family group and all other Series B shareholders have entered into a shareholders’ voting agreement under which all Series B voting common shares will be voted in accordance with the majority vote of Series B voting common shares. Accordingly, through their ownership of voting common shares and the execution of the shareholders’ voting agreement, members of the Johnson family may be deemed, under the Investment Company Act of 1940, to form a controlling group with respect to FMR LLC. Neither FMR LLC nor Abigail P. Johnson has the sole power to vote or direct the voting of the shares owned directly by the various investment companies registered under the Investment Company Act, or the Fidelity Funds, advised by FMR Co. LLC, a wholly owned subsidiary of FMR LLC, which power resides with the Fidelity Funds’ Boards of Trustees. FMR Co. LLC carries out the voting of the shares under written guidelines established by the Fidelity Funds’ Boards of Trustees. This information reflects the securities beneficially owned, or that may be deemed to be beneficially owned, by FMR LLC, certain of its subsidiaries and affiliates, and other companies, collectively referred to as the FMR Reporters. This information does not reflect securities, if any, beneficially owned by certain other companies whose beneficial ownership of securities is disaggregated from that of the FMR Reporters in accordance with Securities and Exchange Commission Release No. 34-39538 (January 12, 1998). The address of the entities and individuals listed above is 245 Summer Street, Boston, Massachusetts 02210.

(6)

Information herein is based on the Schedule 13G filed with the SEC on February 14, 20222024 by Omega Fund VI, L.P. (“Omega Fund”), Omega Fund VI GP, L.P. (“Omega GP”), Omega Fund VI GP Manager, Ltd. (“Omega Ltd”), Claudio Nessi (“Nessi”), Otello Stampacchia (“Stampacchia”), and Anne-Mari Paster (“Paster”) (together, the “Reporting“Omega Reporting Persons”). Omega Fund owns 2,249,123 shares of common stock. Omega Ltd serves as the general partner of Omega GP, which serves as the general partner of Omega Fund, and each of Omega GP and Omega Ltd may be deemed to own beneficially the shares held by Omega Fund. Nessi, Stampacchia, and Paster are the directors of Omega Ltd and may be deemed to beneficially own the shares held by Omega Fund. Each of the Reporting Persons disclaims beneficial ownership of the shares of common stock held by Omega Fund except to the extent of his, her or its pecuniary interest therein. The address of the principal business office of Omega Fund, Omega GP, Omega Ltd, Nessi, Stampacchia, and Paster, is c/o Omega Fund Management, LLC, 888 Boylston Street, Suite 1111, Boston, MA 02199.

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be deemed to beneficially own the shares held by Omega Fund. Each of the Omega Reporting Persons disclaims beneficial ownership of the shares of common stock held by Omega Fund except to the extent of his, her or its pecuniary interest therein. The address of the principal business office of each of the Omega Reporting Persons is c/o Omega Fund Management, LLC, 888 Boylston Street, Suite 1111, Boston, MA 02199.
(7)

Information herein is based on the Schedule 13G filed with the SEC on February 5, 2021 by Celgene Corporation (“Celgene”) and Bristol-Myers Squibb Company with respect to 2,133,142 shares of common stock owned by Celgene, a direct wholly owned subsidiary of Bristol-Myers Squibb Company. Bristol-Myers Squibb Company does not directly own any shares of common stock. By reason of the provisions of Rule 13d-3 under the Act, Bristol-Myers Squibb Company is deemed to own beneficially the Common Stock that Celgene owns as a record holder. The address of the principal business office of Celgene is 86 Morris Avenue Summit, NJ 07901, and the address of the principal business office of Bristol-Myers Squibb Company is 430 East 29th Street, New York, NY 10016.

(8)

Information herein is based on the Schedule 13G/A filed with the SEC on February 14, 2023 by Citadel Advisors LLC (“Citadel Advisors”), Citadel Advisors Holdings LP (“CAH”), Citadel GP LLC (“CGP”), Citadel Securities LLC (“Citadel Securities”), Citadel Securities Group LP (“CALC4”), Citadel Securities GP LLC (“CSGP”) and Mr. Kenneth Griffin (collectively with Citadel Advisors, CAH, CGP, Citadel Securities, CALC4 and CSGP, the “Reporting Persons”) with respect to the shares of common stock owned by Citadel Multi-Strategy Equities Master Fund Ltd. (“CM”), and Citadel Securities. Citadel Advisors is the portfolio manager for CM. CAH is the sole member of Citadel Advisors. CGP is the general partner of CAH. CALC4 is the non-member manager of Citadel Securities. CSGP is the general partner of CALC4. Mr. Griffin is the President and Chief Executive Officer of CGP, and owns a controlling interest in CGP and CSGP. The address of the principal business office of each of the Reporting Persons is Southeast Financial Center, 200 S. Biscayne Blvd., Suite 3300, Miami, Florida 33131.

(9)

Consists of options to purchase 1,212,3651,577,766 shares of our common stock that are exercisable within 60 days of March 31, 2023.

April 1, 2024.
(10)(8)

Consists of options to purchase 107,574241,874 shares of our common stock that are exercisable within 60 days of March 31, 2023.

April 1, 2024.
(11)(9)

Consists of options to purchase 258,274405,026 shares of our common stock that are exercisable within 60 days of March 31, 2023.

April 1, 2024.
(12)(10)

Consists of options to purchase 239,25221,525 shares of our common stock that are exercisable within 60 days of March 31, 2023.

April 1, 2024.
(13)(11)

Consists of options to purchase 22,643263,987 shares of our common stock that are exercisable within 60 days of March 31, 2023.

April 1, 2024.
(14)(12)

Consists of options to purchase 9,73321,525 shares of our common stock that are exercisable within 60 days of March 31, 2023.

April 1, 2024.
(15)(13)

Consists of 44,475 shares of our common stock and options to purchase 2,354,01148,363 shares of our common stock that are exercisable within 60 days of March 31, 2023.

April 1, 2024.
(14)
Consists of options to purchase 21,525 shares of our common stock that are exercisable within 60 days of April 1, 2024.
(15)
Consists of options to purchase 32,885 shares of our common stock that are exercisable within 60 days of April 1, 2024.
(16)
Consists of options to purchase 11,682 shares of our common stock that are exercisable within 60 days of April 1, 2024.
(17)
Consists of options to purchase 2,647,179 shares of our common stock that are exercisable within 60 days of April 1, 2024, and excludes options to purchase shares of our common stock held by Dr. Santillana, who is not a current executive officer.
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REPORT OF THE AUDIT COMMITTEE

The audit committee is appointed by the board of directors to assist the board of directors in fulfilling its oversight responsibilities with respect to (1) the integrity of Ikena’s financial statements and financial reporting process and systems of internal controls regarding finance, accounting, and compliance with legal and regulatory requirements, (2) the qualifications, independence, and performance of Ikena’s independent registered public accounting firm, (3) the performance of Ikena’s internal audit function, if any, and (4) other matters as set forth in the charter of the audit committee approved by the board of directors.

Management is responsible for the preparation of Ikena’s financial statements and the financial reporting process, including its system of internal control over financial reporting and its disclosure controls and procedures. The independent registered public accounting firm is responsible for performing an audit of Ikena’s financial statements in accordance with the standards of the Public Company Accounting Oversight Board (PCAOB) and issuing a report thereon. The audit committee’s responsibility is to monitor and oversee these processes.

In connection with these responsibilities, the audit committee reviewed and discussed with management and the independent registered public accounting firm the audited financial statements of Ikena Oncology, Inc. for the fiscal year ended December 31, 2022.2023. The audit committee also discussed with the independent registered public accounting firm the matters required to be discussed by the PCAOB’s Auditing Standard No. 1301, Communication with Audit Committees. In addition, the audit committee received written communications from the independent registered public accounting firm confirming their independence as required by the applicable requirements of the PCAOB and has discussed with the independent registered public accounting firm their independence.

Based on the reviews and discussions referred to above, the audit committee recommended to the board of directors that the audited financial statements of Ikena Oncology be included in Ikena’s 20222023 Annual Report, that was filed with the SEC. The information contained in this report shall not be deemed to be (1) “soliciting material,” (2) “filed” with the SEC, (3) subject to Regulations 14A or 14C of the Exchange Act, or (4) subject to the liabilities of Section 18 of the Exchange Act. This report shall not be deemed incorporated by reference into any of our other filings under the Exchange Act or the Securities Act, except to the extent that we specifically incorporate it by reference into such filing.

THE AUDIT COMMITTEE OF THE BOARD OF
DIRECTORS OF IKENA ONCOLOGY, INC.
Owen Hughes, Chair
Jean-François Formela, M.D.
Iain Dukes, D.Phil.
April 26, 2024
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THE AUDIT COMMITTEE OF THE BOARD OF
DIRECTORS OF IKENA ONCOLOGY, INC.
Owen Hughes, Chairperson
Jean-François Formela, M.D.
Iain Dukes, D.Phil.

April 28, 2023

HOUSEHOLDING

Some banks, brokers and other nominee record holders may be participating in the practice of “householding” proxy statements and annual reports. This means that only one copy of our documents, including the Annual Report to stockholders and proxy statement, may have been sent to multiple stockholders in your household. We will promptly deliver a separate copy of either document to you upon written or oral request to Ikena Oncology, Inc., 645 Summer Street, Suite 101, Boston, Massachusetts 02210, Attention: Corporate Secretary, telephone 857-273-8342. If you want to receive separate copies of the proxy statement or Annual Report to stockholders in the future, or if you are receiving multiple copies and would like to receive only one copy per household, you should contact your bank, broker or other nominee record holder, or you may contact us at the above address and phone number.

STOCKHOLDER PROPOSALS

A stockholder who would like to have a proposal considered for inclusion in our 20242025 proxy statement must submit the proposal in accordance with the procedures outlined in Rule 14a-8 of the Exchange Act so that it is received by us no later than December 30, 2023.27, 2024. However, if the date of the 20242025 Annual Meeting of Stockholders is changed by more than 30 days from the date of the previous year’s meeting, then the deadline is a reasonable time before we begin to print and send our proxy statement for the 20242025 Annual Meeting of Stockholders. SEC rules set standards for eligibility and specify the types of stockholder proposals that may be excluded from a proxy statement. Stockholder proposals should be addressed to Ikena Oncology, Inc., 645 Summer Street, Suite 101, Boston, Massachusetts 02210, Attention: Corporate Secretary.

To comply with the universal proxy rules, stockholders who intend to solicit proxies in support of director nominees other than the Company’s nominees must provide notice that sets forth the information required by Rule 14a-19 under the Securities Exchange Act of 1934 no later than April 10, 2024.

8, 2025.

If a stockholder wishes to propose a nomination of persons for election to our boardBoard of directorsDirectors or present a proposal at an annual meeting but does not wish to have the proposal considered for inclusion in our proxy statement and proxy card, our bylaws establish an advance notice procedure for such nominations and proposals. Stockholders at an annual meeting may only consider proposals or nominations specified in the notice of meeting or brought before the meeting by or at the direction of the boardBoard of directorsDirectors or by a stockholder of record on the record date for the meeting, who is entitled to vote at the meeting and who has delivered timely notice in proper form to our corporate secretaryCorporate Secretary of the stockholder’s intention to bring such business before the meeting.

The required notice must be in writing and received by our corporate secretaryCorporate Secretary at our principal executive offices not less than 90 days nor more than 120 days prior to the first anniversary of the preceding year’s annual meeting. However, in the event that the date of the annual meeting is advanced by more than 30 days, or delayed by more than 60 days, from the first anniversary of the preceding year’s annual meeting, a stockholder’s notice must be so received no earlier than the 120th day prior to such annual meeting and not later than the close of business on the later of (A) the 90th day prior to such annual meeting and (B) the tenth day following the day on which notice of the date of such annual meeting was mailed or public disclosure of the date of such annual meeting was made, whichever first occurs. For stockholder proposals to be brought before the 20242025 Annual Meeting of Stockholders, the required notice must be received by our corporate secretaryCorporate Secretary at our principal executive offices no earlier than February 10, 20247, 2025 and no later than March 11, 20249, 2025 Stockholder proposals and the required notice should be addressed to Ikena Oncology, Inc., 645 Summer Street, Suite 101, Boston, Massachusetts 02210, Attention: Corporate Secretary.

OTHER MATTERS

Our boardBoard of directorsDirectors does not know of any other matters to be brought before the Annual Meeting. If any other matters not mentioned in this proxy statement are properly brought before the meeting, the individuals named in the enclosed proxy intend to use their discretionary voting authority under the proxy to vote the proxy in accordance with their best judgment on those matters.

LOGO

IKENA ONCOLOGY, INC.

645 SUMMER STREET, SUITE 101

BOSTON, MA 02210

33

    LOGOTABLE OF CONTENTS

VOTE BY INTERNET

Before The Meeting - Go to www.proxyvote.com or scan the QR Barcode above

Use the Internet to transmit your voting instructions and for electronic delivery of information up until 11:59 p.m. Eastern Time the day before the cut-off date or meeting date. Have your proxy card in hand when you access the web site and follow the instructions to obtain your records and to create an electronic voting instruction form.

During The Meeting - Go to www.virtualshareholdermeeting.com/IKNA2023

You may attend the meeting via the Internet and vote during the meeting. Have the information that is printed in the box marked by the arrow available and follow the instructions.

VOTE BY PHONE - 1-800-690-6903

Use any touch-tone telephone to transmit your voting instructions up until 11:59 p.m. Eastern Time the day before the cut-off date or meeting date. Have your proxy card in hand when you call and then follow the instructions.

VOTE BY MAIL

Mark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717.


 

TO VOTE, MARK BLOCKS BELOW IN BLUE OR BLACK INK AS FOLLOWS:

V11971-P94273                    KEEP THIS PORTION FOR YOUR RECORDS

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DETACH AND RETURN THIS PORTION ONLY

THIS PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED.

IKENA ONCOLOGY, INC.

For

All

Withhold

All

For All

Except

To withhold authority to vote for any individual

nominee(s), mark “For All Except” and write the

number(s) of the nominee(s) on the line below.

The Board of Directors recommends you vote FOR the following:

1.  To elect three class II directors to our board of directors, to serve until the 2026 annual meeting of stockholders and until their successor has been duly elected and qualified, or until their earlier death, resignation or removal.

☐

☐

☐

Nominees:

01) David Bonita, M.D.

02) Jean-Francois Formela, M.D.

03) Richard Wooster, Ph.D.

The Board of Directors recommends you vote FOR the following proposal:ForAgainstAbstain

2.  To ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2023.

☐☐☐

To transact any other business properly brought before the Annual Meeting or any adjournment or postponement of the Annual Meeting.

Please sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor, administrator, or other fiduciary, please give full title as such. Joint owners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name by authorized officer.

Signature [PLEASE SIGN WITHIN BOX]DateSignature (Joint Owners)Date

Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting:

The Notice and Proxy Statement, Annual Report and Form 10-K are available at www.proxyvote.com.

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V11972-P94273            

TABLE OF CONTENTS

IKENA ONCOLOGY, INC.

THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

ANNUAL MEETING OF STOCKHOLDERS

JUNE 9, 2023

The stockholder(s) hereby appoint(s) Mark Manfredi, Ph.D. and Jotin Marango, M.D., Ph.D., or either of them, as proxies, each with the power to appoint his substitute, and hereby authorize(s) them to represent and to vote, as designated on the reverse side of this ballot, all of the shares of Common Stock of Ikena Oncology, Inc. that the stockholder(s) is/are entitled to vote at the Annual Meeting of Stockholder s to be held online at 8:30 a.m., Eastern Time on Friday, June 9, 2023, and any adjournment or postponement thereof.

THIS PROXY, WHEN PROPERLY EXECUTED, WILL BE VOTED AS DIRECTED BY THE STOCKHOLDER(S). IF NO SUCH DIRECTIONS ARE MADE, THIS PROXY WILL BE VOTED FOR THE ELECTION OF THE NOMINEES LISTED ON THE REVERSE SIDE FOR THE BOARD OF DIRECTORS AND FOR PROPOSAL 2.

PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY USING THE ENCLOSED REPLY ENVELOPE

CONTINUED AND TO BE SIGNED ON REVERSE SIDE